On the resemblance of synapse formation and CNS myelination

Almeida, Rafael; Lyons, David A.

doi:10.1016/j.neuroscience.2013.08.062

Cited by 38 publications

(36 citation statements)

References 143 publications

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“…However, whether these drugs have the same effect on synaptic vesicle release in the PNS, as shown in the CNS [44,55], should be carefully tested in the future. Synaptic vesicle release might be responsible for myelin ensheathment in the CNS as it has been proposed a synaptic-like interaction between OLs and axons [43,44,56], nevertheless its role in nodes organization has not been tested yet. SNAP25 and NSF have been shown to be involved in both types of constitutive and regulated exocytosis as SNARE proteins and NSF are essential for all intracellular membrane fusion events [26,27,57].…”

Section: Discussionmentioning

confidence: 99%

Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish

et al. 2016

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Axon ensheathment by specialized glial cells is an important process for fast propagation of action potentials. The rapid electrical conduction along myelinated axons is mainly due to its saltatory nature characterized by the accumulation of ion channels at the nodes of Ranvier. However, how these ion channels are transported and anchored along axons is not fully understood. We have identified N-myc downstream-regulated gene 4, ndrg4, as a novel factor that regulates sodium channel clustering in zebrafish. Analysis of chimeric larvae indicates that ndrg4 functions autonomously within neurons for sodium channel clustering at the nodes. Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE/NSF machinery.

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Section: Discussionmentioning

confidence: 99%

Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish

et al. 2016

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“…A model often termed “activity-dependent myelination” posits that changes in synaptic inputs to OPCs could serve as an inductive cue, causing OPC differentiation and myelination of the axons providing modified inputs, perhaps even converting axon-OPC synapses into a myelinating sheath (Figure 1A) [41]. This process could shape brain development based on experience or contribute to learning by modifying circuit timing.…”

Section: Axonal Cues For Axon Selectionmentioning

confidence: 99%

Architecting the myelin landscape

Osso

Chan

2017

Current Opinion in Neurobiology

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Myelin increases the speed and efficiency of action potential propagation. Yet, not all axons are myelinated and some axons are discontinuously myelinated, prompting the question of how myelinating glia select axons for myelination. Whereas myelination by Schwann cells depends on axonal induction, oligodendrocytes can form myelin membrane in the absence of axons. However, oligodendrocytes alone cannot architect the complex myelination patterns of the central nervous system and recent advances have implicated axonal signaling in this process. This review considers how oligodendrocytes and their precursors could be influenced by inductive, attractive, permissive, repulsive, and preventative cues, and discusses recent evidence identifying synaptic activity and membrane-bound adhesion molecules as such cues directing axon selection.

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“…OPCs (also known as Ng2 cells in rodents) have also been considered by some to be a separate differentiated class of glial cell (for discussion, see Mangin and Gallo 2011;Almeida and Lyons 2013). However, it is clear that their general dynamic behavior and ability to generate OLs is conserved not only between zebrafish and rodents, but also between embryonic spinal cord and adult cortex.…”

Section: Oligodendrocyte Precursor Cells (Opcs)mentioning

confidence: 99%

Glial Cell Development and Function in Zebrafish

Lyons

Talbot

2014

Cold Spring Harb Perspect Biol

111

100

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The zebrafish is a premier vertebrate model system that offers many experimental advantages for in vivo imaging and genetic studies. This review provides an overview of glial cell types in the central and peripheral nervous system of zebrafish. We highlight some recent work that exploited the strengths of the zebrafish system to increase the understanding of the role of Gpr126 in Schwann cell myelination and illuminate the mechanisms controlling oligodendrocyte development and myelination. We also summarize similarities and differences between zebrafish radial glia and mammalian astrocytes and consider the possibility that their distinct characteristics may represent extremes in a continuum of cell identity. Finally, we focus on the emergence of zebrafish as a model for elucidating the development and function of microglia. These recent studies have highlighted the power of the zebrafish system for analyzing important aspects of glial development and function.

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On the resemblance of synapse formation and CNS myelination

Cited by 38 publications

References 143 publications

Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish

Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish

Architecting the myelin landscape

Glial Cell Development and Function in Zebrafish

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