On the Reliability of Suction Measurements for Skin Characterization

Mueller, Beate; Elrod, Julia; Distler, Oliver; Schiestl, Clemens; Mazza, Edoardo

doi:10.1115/1.4047661

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…Flexibility (R0 value) increased from 0.121 mm to 0.198 mm (+63.6%) by the vacuum treatment. This improved value approaches the reference value of the control arm (0.356 mm) and is directly related with reduction in tissue fibrosis ( Mueller et al, 2021 ). The treated area showed a conserved ability to return to its initial position after flexing, as R1 value was similar to control arm (0.047 vs. 0.036 mm).…”

Section: Case Descriptionmentioning

confidence: 59%

Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration

Obaíd

Carvajal

Camacho

et al. 2022

Front. Bioeng. Biotechnol.

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It is broadly described that almost every step of the regeneration process requires proper levels of oxygen supply; however, due to the vascular disruption in wounds, oxygen availability is reduced, being detrimental to the regeneration process. Therefore, the development of novel biomaterials combined with improved clinical procedures to promote wound oxygenation is an active field of research in regenerative medicine. This case report derives from a cohort of patients enrolled in a previously published ongoing phase I clinical trial (NCT03960164), to assess safety of photosynthetic scaffolds for the treatment of full skin defects. Here, we present a 56 year old patient, with a scar contracture in the cubital fossa, which impaired the elbow extension significantly affecting her quality of life. As part of the treatment, the scar contracture was removed, and the full-thickness wound generated was surgically covered with a photosynthetic scaffold for dermal regeneration, which was illuminated to promote local oxygen production. Then, in a second procedure, an autograft was implanted on top of the scaffold and the patient’s progress was followed for up to 17 months. Successful outcome of the whole procedure was measured as improvement in functionality, clinical appearance, and self-perception of the treated area. This case report underscores the long-term safety and applicability of photosynthetic scaffolds for dermal regeneration and their stable compatibility with other surgical procedures such as autograft application. Moreover, this report also shows the ability to further improve the clinical outcome of this procedure by means of dermal vacuum massage therapy and, more importantly, shows an overall long-term improvement in patient´s quality of life, supporting the translation of photosynthetic therapies into human patients.

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Section: Case Descriptionmentioning

confidence: 59%

Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration

Obaíd

Carvajal

Camacho

et al. 2022

Front. Bioeng. Biotechnol.

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“…Integrating this basis with recent breakthroughs in tissue fabrication, biophysics, and biomaterials, should enable bottom-up strategies for the design of bioreactors that are well-suited to investigate the mechanobiology of HP and OS. Novel methods in 3D tissue bioprinting [159][160][161][162][163], mechanical characterization of biological tissues [164][165][166][167][168][169], the formulation of responsive biomaterials with tunable biomechanical and biochemical properties [170][171][172][173][174][175][176], and the development of 3D organotypic cell cultures [177][178][179][180][181][182] highlight a battery of innovations that can be exploited towards the design of advanced materials systems and bioreactors for the control of HP and OS.…”

Section: Conventional and Advanced Bioreactors For 3d Mechanobiologic...mentioning

confidence: 99%

“…Finally, the discovery of new physical indicators of the cell microenvironment will be critical to measure the effects of HP and OS. For this purpose, bioreactors integrated with various techniques of in situ characterization [167][168][169][247][248][249][250][251] shall reveal new physical and biochemical patterns of cell behavior, closely correlated with the role of HP and OS in cell mechanobiology. Beyond fundamental insight, we envision that a deeper understanding of the mechanobiology of HP and OS can lead to advanced therapies.…”

Section: Future Perspective For In Vitro Systems To Study Hydrostatic...mentioning

confidence: 99%

Control of hydrostatic pressure and osmotic stress in 3D cell culture for mechanobiological studies

Kourouklis

Wahlsten

Stracuzzi

et al. 2023

Biomaterials Advances

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“…There are a large number of models in the literature designed to fit different families of materials. Even in specific fields such as skin mechanics there is no consensus on the choice of a material model [21,22,23]. Furthermore, the analytical form of the strain energy function may be too restrictive for many applications, resulting in poor prediction performance.…”

Section: Introductionmentioning

confidence: 99%

Data-driven Tissue Mechanics with Polyconvex Neural Ordinary Differential Equations

Tac,

Costabal,

Tepole

2021

Preprint

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Data-driven methods are becoming an essential part of computational mechanics due to their unique advantages over traditional material modeling. Deep neural networks are able to learn complex material response without the constraints of closed-form approximations. However, imposing the physics-based mathematical requirements that any material model must comply with is not straightforward for data-driven approaches. In this study, we use a novel class of neural networks, known as neural ordinary differential equations (N-ODEs), to develop data-driven material models that automatically satisfy polyconvexity of the strain energy function with respect to the deformation gradient, a condition needed for the existence of minimizers for boundary value problems in elasticity. We take advantage of the properties of ordinary differential equations to create monotonic functions that approximate the derivatives of the strain energy function with respect to the invariants of the right Cauchy-Green deformation tensor. The monotonicity of the derivatives guarantees the convexity of the energy. The N-ODE material model is able to capture synthetic data generated from closed-form material models, and it outperforms conventional models when tested against experimental data on skin, a highly nonlinear and anisotropic material. We also showcase the use of the N-ODE material model in finite element simulations. The framework is general and can be used to model a large class of materials. Here we focus on hyperelasticity, but polyconvex strain energies are a core building block for other problems in elasticity such as viscous and plastic deformations. We therefore expect our methodology to further enable data-driven methods in computational mechanics.

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On the Reliability of Suction Measurements for Skin Characterization

Cited by 12 publications

References 29 publications

Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration

Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration

Control of hydrostatic pressure and osmotic stress in 3D cell culture for mechanobiological studies

Data-driven Tissue Mechanics with Polyconvex Neural Ordinary Differential Equations

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