ON THE RELATIONSHIPS BETWEEN THE γ-GLOBULIN GENES OF THE G<scp>M</scp> SYSTEM

Mårtensson, Linda

doi:10.1084/jem.120.6.1169

Cited by 35 publications

(15 citation statements)

References 13 publications

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“…After having been washed repeatedly each cell suspension was tested with several dilutions of various anti-Gm agglutinators. The technique used in this test has been described before [21].…”

Section: Two-dimensional Titrations Of Anti-gm Reagents Against Anti-mentioning

confidence: 99%

Gm(s) and Gm(t): Genetic Determinants of Human γ‐Globulin*

et al. 1966

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Summary Two genetic determinants of human γ‐globulin, Gm(s) and Gm(t), were identified. Résumé Deux »nouveaux« déterminants génétiques des gamma‐globulines humaines ont été identifiés; ce sont les déterminants Gra(s) et Gm(t). Type Gm(s +) occurred in 38% of 176 Japanese, 31% of 75 Eskimoes of Western Greenland, 21% of 188 Suriname Negroes, 14% of 110 West African Negroes, and only in about 1% of 910 Europeans. All Gm (s+) sera were Gm(b3+); and all Gm(b1‐b3+) sera were Gm(s +). This suggests an allele at the Vi locus, called Gmsb or Gmsb(3), that is partly identical with and partly different from Gmb (= Gmb(1,3)), — the most common Vi allele in Caucasians. Gm(s) appeared to be inherited together with the determinants Gm(a) and (b3) in the Mongoloid populations and in 4 of the 6 European families studied. This suggests that Gmsb is as a rule coupled with a Gma gene at the We locus in Mongoloids and often (but not always) coupled with Gma also in Caucasians. Gmb, by contrast, appears to be coupled with Gmf or with Gmaf in Caucasians and Mongoloids. Gm(t) was found together with Gm(s) in Japanese, but not in Negroes. The Japanese were Gm(s + t +) and Gm(s‐t ‐); the Negroes were Gm(s + t ‐) and Gm(s‐t‐). Of the 13 unrelated Gm(s +) Caucasians that have been found 9 were Gm(s + t +) and 4 Gm(s + t‐). A genetic hypothesis for the Gm system is presented. The Gm specificities are ascribed to 3 separate genzetic regions: one region that determines Gm(a); a second that determines Gm(f); and a third that determines the Gm(b) specificities and probably Gm(c), (s), and (t). The Gm(f) region is located between the Gm(a) and the Gm(b) region. Zusammenfassung Es wurden zwei »neue« genetische Determinanten des menschlichen Gamma‐Globulins, Gm(s) und Gm(t), identifiziert. Le type Gm(s +) se rencontre chez 38% des 176 Japonais examinés, chez 31% des 75 Esquimaux du Grœnland occidental, 21% des 188 noirs du Suriname, 14% des 110 noirs de l'Afrique occidentale et seulement chez 1% des 910 européens. Tous les sérums Gm(s +) sont Gm(b3 +); tous les sérums Gm(b1‐b3+) sont Gm(s +). Cela suppose qu'il y a un allèle sur le locus Vi, qui se nomme Gmsb ou Gmsb(3) et qui est en partie identique et en partie différent de Gmb (=Gmb(1,3′)) lequel est l'allèle du locus Vi le plus souvent chez les habitants du Caucase. Gm(s) semble être hérité avec les déterminants Gm(a) et (b3) chez la population mongoloïde et dans 4 des six families européennes observées. On suppose que Gmsb est en général couplé avec le gène Gma sur le locus We chez les Mongols et souvent, mais pas toujours, avec Gma chez les Caucasiens. Gmb, au contraire, semble être couplé avec Gmf ou Gmaf chez les Caucasiens et les Mongols. Gm(t) fut trouvé simultanément avec le déterminant Gm(s) chez les Japonais, mais non chez les noirs. Les Japonais sont Gm(s+t +) et Gm(s ‐ t ‐); les noirs sont Gm(s + t ‐) et Gm(s‐t‐). Sur 13 Caucasiens Gm(s +), 9 sont Gm(s + t +) et 4 Gm(s + t ‐). On présente une hypothèse génétique du système Gm. Les spécificités Gm sont circonscrites à 3 régions...

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Section: Two-dimensional Titrations Of Anti-gm Reagents Against Anti-mentioning

confidence: 99%

Gm(s) and Gm(t): Genetic Determinants of Human γ‐Globulin*

et al. 1966

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“…Gm(a +fbl-) cificities Gm(a) and Gm(f) suggest that each of them is carried by a much larger proportion (one t o two thirds) of the molecules [47]. Furthermore, the assumption that the frequencies of the Gm types among myeloma proteins (Table 11) reflect their frequencies among normal yG molecules, would also imply that Gm(a) and Gm(f) occur in a large, Gm(bl) in a much smaller, percentage of the yG molecules.…”

Section: A Myeloma Proteinsmentioning

confidence: 99%

Genes and Immunoglobulins

Mårtensson¹

1966

Vox Sanguinis

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“…Of interest in this regard were proteins Blix, Lavelle, and Smith which, after pepsin digestion, showed S20, w* values of 1.4, 2.0, and 1.8 S, respectively, but which retained full inhibitory capacity for the pepsin site with the entire panel of agglutinators and pepsin-digested coats. 7.0 S20, wo and 5.0 S20, w" after digestion.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, a correlation between the retention of inhibitory capacity in the pepsin site agglutination system and the typing of individual myelomas for Gm(a) (4, 5), Gm(b) (6), and Gm(f) (7,8) was sought, particularly since Gm(f) has been localized to the Fab-fragment (9). Also, it seemed possible that retention or loss of the pepsin site might be related to the H-chain subgroups recently described from several laboratories (1,2).…”

mentioning

confidence: 99%