On the relationship between measles virus and Alzheimer neurofibrillary tangles in subacute sclerosing panencephalitis

Bancher, C.; Leitner, H.; Jellinger, K. A.; Eder, H. T.; Setinek, U.; Fischer, Peter; Węgiel, Jerzy; Wisniewski, H. M.

doi:10.1016/0197-4580(96)00069-3

Cited by 39 publications

(17 citation statements)

References 34 publications

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“…Neurofibrillary tangles are found in the brains of individuals who experienced frontotemporal lobar degeneration with tauopathy (FTLD-MAPT), focal cortical dysplasia, myotonic dystrophy, prion diseases, metabolic/storage diseases, some brain tumors, chronic traumatic encephalopathy, viral encephalitis, and other brain diseases (34-37) (Table 3). This suggests that NFTs are, at least under some conditions, a secondary response to injury.…”

Section: Aβps and Neurofibrillary Tangles: The Histopathologic Hallmamentioning

confidence: 99%

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson

Alafuzoff

Bigio

et al. 2012

J Neuropathol Exp Neurol

1,663

1,401

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Section: Aβps and Neurofibrillary Tangles: The Histopathologic Hallmamentioning

confidence: 99%

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson

Alafuzoff

Bigio

et al. 2012

J Neuropathol Exp Neurol

1,663

1,401

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“…NFTs are also found in the brains of individuals who suffered from FTLD with tauopathy (FTLD-MAPT), myotonic dystrophy, prion diseases, metabolic diseases, some brain tumors, chronic traumatic encephalopathy, viral encephalitis, and other brain diseases [18–21] (conditions collectively termed “tauopathies”). This suggests that NFTs are, at least under some conditions, a secondary response to injury.…”

Section: Brain Pathologies Linked To Aging: Prevalence and Impact mentioning

confidence: 99%

Is synaptic loss a unique hallmark of Alzheimer's disease?

Scheff

Neltner

Nelson

2014

Biochemical Pharmacology

105

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Synapses may represent a key nidus for dementia including Alzheimer's disease (AD) pathogenesis. Here we review published studies and present new ideas related to the question of the specificity of synapse loss in AD. Currently, AD is defined by the regional presence of neuritic plaques and neurofibrillary tangles in the brain. The severity of involvement by those pathological hallmarks tends to correlate both with antemortem cognitive status, and also with synapse loss in multiple brain areas. Recent studies from large autopsy series have led to a new standard of excellence with regard to clinical–pathological correlation and to improved comprehension of the numerous brain diseases of the elderly. These studies have provided evidence that it is the rule rather than the exception for brains of aged individuals to demonstrate pathologies (often multiple) other than AD plaques and tangles. For many of these comorbid pathologies, the extent of synapse loss is imperfectly understood but could be substantial. These findings indicate that synapse loss is probably not a hallmark specific to AD but rather a change common to many diseases associated with dementia.

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“…Repetitive head trauma can lead to a dementing state both clinically and pathologically similar to Alzheimer’s disease, termed dementia pugilistica [71]. Subacute sclerosing panencephalitis, which presents with NFT pathology, can arise as a rare late complication of infection with measles [72].…”

Section: Lrrk2: Marshalling Pleiomorphic Pathologymentioning

confidence: 99%

Emerging pathways in genetic Parkinson’s disease: tangles, Lewy bodies and LRRK2

Devine

Lewis

2008

The FEBS Journal

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The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in α‐synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson’s disease, characterized by variable pathology including either α‐synuclein or tau deposition, it has been suggested that LRRK2 functions as an upstream regulator of Parkinson’s disease pathogenesis. This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, α‐synuclein and tau.

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On the relationship between measles virus and Alzheimer neurofibrillary tangles in subacute sclerosing panencephalitis

Cited by 39 publications

References 34 publications

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Is synaptic loss a unique hallmark of Alzheimer's disease?

Emerging pathways in genetic Parkinson’s disease: tangles, Lewy bodies and LRRK2

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