On the relationship between aging &amp; cancer

Ja, Betancourt-Mar; Mansilla, Ricardo; Cocho, G.; Rr, Martin; Montero, S.; Jm, Nieto-Villar

doi:10.15406/mojgg.2018.03.00103

Cited by 2 publications

(7 citation statements)

References 55 publications

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“…7, describes the aging process as the first order phase transitions. A similar result is found in a previous work for healthy humans and patients with metastatic carcinoma [25].…”

Section: The Entropy Production Rate For the Rats And Mole-ratssupporting

confidence: 92%

“…The most significant is that according to O'Connor et al [17,50], metabolic rate of the Naked mole-rat did not change significantly with age, which implies that unlike rats (see Fig. 1,2) and humans [25], the rate of entropy production per body mass is a constant during life, which gives it a high degree of robustness (plasticity) [32,33,34]. This result is consistent with the hypothesis that naked mole rats are characterized by neoteny with the preservation of the characteristics of adolescences [51] and could be explain the high resistance to the degenerative diseases of the moles rats.…”

Section: The Entropy Production Rate For the Rats And Mole-ratsmentioning

confidence: 81%

“…As point out by Strehler [46], who defines aging by means of four postulates, we could add a fifth one: the aging processes are a complex network of interactions self-organized in time and space, far from thermodynamic equilibrium, exhibiting high complexity, robustness and adaptability, whose physiological functions decline with age [25].…”

Section: The Entropy Production Rate For the Rats And Mole-ratsmentioning

confidence: 99%

“…A thermodynamics viewpoint may be useful for theory testing, since the adequacy of a postulated mechanism of aging is best judged by its compatibility with senescent changes [24]. In a previous study [25] we described the relationship between aging and cancer for healthy humans and patients with metastatic carcinoma in a unified approach from the perspective of thermodynamics. However, to our best knowledge, there are not reports related to thermodynamics analysis of the longevity of the mole-rats.…”

Section: Introductionmentioning

confidence: 99%

“…The main purpose of the present work is to extend the thermodynamics formalism previously developed [25] to discuss the relationship of the longevity between the molerats and rats. The manuscript is organized as follow: In Section 2 is presented a theoretical framework based on thermodynamic formalism, particularly the entropy production rate due to metabolic rate.…”

Section: Introductionmentioning

confidence: 99%

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Entropy production as a physical pacemaker of lifespan in mole-rats

2018

IJOAR

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Research Article IJOAR (2018) 1:22 Entropy production as a physical pacemaker of lifespan in molerats This work discusses the relationship of the biological aging between mole-rats and rats through a unified approach from the perspective of thermodynamics. Taking calorimetric data from some published studies of the metabolism on mole-rats and rats, it is calculated the entropy production rate. It is observed that the entropy production rate in rats decays with chronological age, and develops a kind of first order phase transition. However, the mole-rats, showed that entropy production rate did not change significantly with age and exhibits a slightly higher value as an average compared to the rats analyzed. This result can be interpreted in terms of a mole-rats exhibit a more robustness, i.e. greater plasticity than rats. Furthermore, it is shown that the entropy production rate could be consider as a physical marker of biological age and a predictor of Lifespan.

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“…7, describes the aging process as the first order phase transitions. A similar result is found in a previous work for healthy humans and patients with metastatic carcinoma [25].…”

Section: The Entropy Production Rate For the Rats And Mole-ratssupporting

confidence: 92%

Section: The Entropy Production Rate For the Rats And Mole-ratsmentioning

confidence: 81%

Section: The Entropy Production Rate For the Rats And Mole-ratsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Entropy production as a physical pacemaker of lifespan in mole-rats

2018

IJOAR

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General thermodynamic efficiency loss, aging and Gompertz mortality law

Montemayor-Aldrete

Márquez-Caballé

2020

Supl. Rev. Mex. Fis.

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A simple and general thermodynamic theory is applied to describe the irreversible aspects of the continuous process of functional efficiency loss, which occurs in dissipative biological structures after they reach maturity [1]. This theory, among other things, follows Prigogine [2] by considering that these dissipative structures perform their functions and carry out cyclical processes per se since they are self-organizing away from equilibrium. By using the irreversible thermodynamic theory of aging by Montemayor-Aldrete et al [1], we have obtained results such as the following: The accumulated damage that occurs in dissipative biological structures after they reach maturity, which is the product of linear loss of functional efficiency with time, leads to the law of exponential mortality rate by Gompertz. The average solar power volumetric density of frequency ν dissipated by circular molecules of radius , which reside on the inner surface of some lipid vesicles that float in the Archean oceans and that contain water and other chemical components are obtained. Such expression resembles the Stefan–Boltzmann law which describes the power radiated from a black body in terms of its temperature. Also, an expression for the volumetric density of the average entropy production rate by molecules of radius is obtained. Finally, the coupling processes that occur between the matter and heat fluxes between the interior and the exterior of lentil-shaped lipid vesicles pumped by the solar radiation action are analyzed qualitatively as well as their possible consequences in relation to the prebiotic chemical evolution of dissipative systems that can give rise to life.

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On the relationship between aging & cancer

Cited by 2 publications

References 55 publications

Entropy production as a physical pacemaker of lifespan in mole-rats

Entropy production as a physical pacemaker of lifespan in mole-rats

General thermodynamic efficiency loss, aging and Gompertz mortality law

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