On the Relation of Lipase to Fat Metabolism—lipogenesis

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

A study of the reaction of lymphatic endothelium and of leucocytes, in the tadpole's tail, toward injected fat

“…The mechanism by which the fat which is resynthesized in the intestinal mucosa, reaches the central lacteals of the villi, has not been clearly demonstrated. Loevenhart (19) advanced the theory, based upon his observations of the reversible action of lipase, that the neutral fat, present in the intestinal cells during fat absorption, represented merely a stable phase in the reaction and that the absorbed fat was continually leaving the intestinal cells and entering the lymphatics in a soluble form, probably fatty acids, and was resynthesized somewhere in the J ymphatic system (Loevenhart had previously shown that lipase is present in the lymph and the lymph glands). B.…”

Some factors influencing the lipase content of the blood

“…During a fasti l1g period the sera-lipase of pups decrea s e s i n u marked degre e from &bout the fourth to the sixth day, begi n s to i ncrease about the eighth day a l1(1 conti nues t o i n crease thro ughout t he remai nder of the fast. , 4. The sero-lipase in grovm dogs decreases rapidly during the first four or five days of a fast, then remains at nea rly a co n stan t level f or two or three days,after v 7h1ch it gradually i ncreases to the end of the fast.…”

“…They also found the pancreas, liver, kidney and submax~llary gland to possess lipolytic activity. 4 In 1902 Loevenhart in studying the method of fat absorption found tha t the intestinal mucosa \vas actively lipolytic toward ethyl but'yrate.…”