On the Relation Between Transcutaneous Oxygen Tension and Skin Blood Flow

BackgoundThe identification of potential sources of error is a crucial step for any new assessment technique. This is the case for transcutaneous variables, such as flow and arterial gases, which have been applied as functional indicators of various aspects of human health. Regarding gender, a particular subject-related determinant, it is often claimed that women present higher transcutaneous oxygen pressure (tcpO2) values than men. However, the statistical significance of this finding is still uncertain.MethodsThe haemodynamical-vascular response to a local reactive hyperaemia procedure (the tourniquet cuff manoeuvre) was studied in two previously selected group of volunteers (n = 16; 8 women and 8 men). The effect of gender was assessed under standardised experimental conditions, using the transcutaneous flow-related variables tcpO2-tcpCO2 and Laser-doppler Flowmetry (LDF).ResultsRegarding tcpO2, statistically significant differences between genders were not found, although higher values were consistently found for the gases in the female group. Regarding LDF, high statistically significant differences (p < 0.005) were found, with the men's group presenting the highest values and variability. Other derived parameters used to characterise the vascular response following the cuff-deflation (t-peak) were similar in both groups.ConclusionsThe relative influence of gender was not clearly demonstrated using these experimental conditions. However the gender-related LDF differences suggest that further investigation should be done on this issue. Perhaps in the presence of certain pathological disparities involving peripheral vascular regulation, other relationships may be found between these variables.

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“…all volunteers adopted the seated position in order to avoid any hemodinamical changes influencing measurements [1,24,25]…”

Section: Methodsmentioning

confidence: 99%

Transcutaneous flow related variables measured in vivo: the effects of gender

2001

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“…They gave informed consent to a protocol approved by the local ethical committee. Mean age was 32.5 ±6.1 (SD) years (range [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] with a mean Quetelet index of 22.3 ±2.4 (SD) kg/m2.. The volunteers had to abstain from smoking for twenty-four hours and from caffeine-or alcohol-containing beverages for twelve hours and to refrain from food or liquid intake during the two hours preceding the test.…”

Section: Methodsmentioning

confidence: 99%

Hemodynamic Effects of Prostacyclin Infusions in Healthy Volunteers

Wollersheim

Thien

1988

Angiology

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The selective hemodynamic effects of an intravenous infusion of prostacyclin on skin and on forearm blood flow during increasing doses up to 6 ng.kg.-1 min.-1 were evaluated in 12 healthy volunteers. The highest dose raised total skin blood flow (p = 0.0001) as measured by laser Doppler with a concomitant rise in finger skin temperature (p = 0.02). Capillary perfusion as measured by transcutaneous oxygen monitoring remained relatively unaffected (p = 0.25). Cold-induced vasoconstriction and the recovery thereafter were not influenced. Diastolic blood pressure tended to decrease (p = 0.06), but there was no change in systolic blood pressure, forearm blood flow, and calculated forearm vascular resistance. The authors conclude that prostacyclin may have dissimilar vasoactive potencies in different vascular beds as shown by a pronounced increase in total skin blood flow, owing to vasodilation of shunt vessels, simultaneously with an insignificant change in nutritional skin blood flow and forearm muscle blood flow.

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“…Furthermore, the pres¬ ence of arteriovenous shunts may modify the capillary response to local warming, and the effects of warming may be inconsistent in different regions. 10 Increased TCOM reliability may be obtained by having the subject breathe 100% oxygen." Perfused, via¬ ble tissue responds with increased TCOM readings within seconds.…”

Section: One-time Assessment Of Multiple Sitesmentioning

confidence: 99%

Comparative Assessment of Blood Flow to Canine Island Flaps

Silverman¹,

Weinstock²,

Brousseau³

et al. 1985

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\Fluorometric quantification of dye delivery, laser Doppler flowmetry, and transcutaneous measurement of tissue oxygen level were evaluated in canine island flaps subjected to vascular occlusion. Each technique readily identified the clamping insult. Relative fluorescein delivery to the flap (compared with a reference area) decreased from 66% before clamping to almost zero during clamping. Laser Doppler readings rapidly declined from an average of 230 to an average of 31 mV.

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On the Relation Between Transcutaneous Oxygen Tension and Skin Blood Flow

Cited by 21 publications

References 14 publications

Transcutaneous flow related variables measured in vivo: the effects of gender

Transcutaneous flow related variables measured in vivo: the effects of gender

Hemodynamic Effects of Prostacyclin Infusions in Healthy Volunteers

Comparative Assessment of Blood Flow to Canine Island Flaps

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