On the problem of the harmful effect of DDT and its mechanism of action

Kagan, Yu. S.; Fudel-Ossipova, S. I.; Khaikina, B. J.; Kuz'minskaya, U. A.; Kouton, S. D.

doi:10.1007/978-1-4615-8449-0_3

Cited by 5 publications

(2 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That goal proved elusive, however. Between the 1940s and 1970s, scientists reported increasing insect resistance, mammalian toxic effects, and environmental persistence of chlorinated hydrocarbon insecticides (87, 88). These problems stimulated a search for alternative insecticides.…”

Section: Accepting Plague Persistencementioning

confidence: 99%

Living with plague: Lessons from the Soviet Union’s antiplague system

Jones

Atshabar

Schmid

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Zoonoses, such as plague, are primarily animal diseases that spill over into human populations. While the goal of eradicating such diseases is enticing, historical experience validates abandoning eradication in favor of ecologically based control strategies (which reduce morbidity and mortality to a locally accepted risk level). During the 20th century, one of the most extensive plague-eradication efforts in recorded history was undertaken to enable large-scale changes in land use in the former Soviet Union (including vast areas of central Asia). Despite expending tremendous resources in its attempt to eradicate plague, the Soviet antiplague response gradually abandoned the goal of eradication in favor of plague control linked with developing basic knowledge of plague ecology. Drawing from this experience, we combine new gray-literature sources, historical and recent research, and fieldwork to outline best practices for the control of spillover from zoonoses while minimally disrupting wildlife ecosystems, and we briefly compare the Soviet case with that of endemic plague in the western United States. We argue for the allocation of sufficient resources to maintain ongoing local surveillance, education, and targeted control measures; to incorporate novel technologies selectively; and to use ecological research to inform developing landscape-based models for transmission interruption. We conclude that living with emergent and reemergent zoonotic diseases—switching to control—opens wider possibilities for interrupting spillover while preserving natural ecosystems, encouraging adaptation to local conditions, and using technological tools judiciously and in a cost-effective way.

show abstract

Section: Accepting Plague Persistencementioning

confidence: 99%

Living with plague: Lessons from the Soviet Union’s antiplague system

Jones

Atshabar

Schmid

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Were insecticide precipitation to occur, the potential for coprecipitating carbonic anhydrase would exist since the enzyme is known to be present in various tissues in concentrations varying between ~10"8 and 10"6 m (Maren, 1967). It is known that DDT affects many other enzymes (Kagan et al, 1969) and conclusions about specific environmental effects on DDT and DDE should await further investigation. We would caution that other studies also include DDE as some people are tempted to conclude that DDE is a harmless decomposition product of DDT.…”

Section: Discussionmentioning

confidence: 99%