" on the Position of Ship Surgeons."

Abstract

To the Editor of THE LANCET. SIR,—I quite agree with some of the difficulties mentioned in Dr. Irwin's letter of the 17th inst., with which a ship surgeon has to contend, and I think there is another difficulty which might be added to Dr. Irwin's list, and this is, the unpleasantness the ship surgeon often meets with, when doing his duty, in laying-up some of the crew. Accidents happen in smooth as well as in rough weather, and there is always a certain amount of rheumatism and bronchitis (according to the weather); these cases, of course, tend to diminish the number of the "watch." The cases I am about to mention are tho:;e of sprains, onychia, buboes, orchitis, aneurisms, and other ailments, about which the doctor is

Frataxin knockin mouse

“…The neuropathology in FRDA is characterized by loss of large sensory neurons in the dorsal root ganglia, atrophy of the large sensory fibers in peripheral nerves, of the posterior columns, spinocerebellar and pyramidal tracts in the spinal cord and of the dentate nucleus in the cerebellum [4]. Patients show progressive gait and limb ataxia, dysarthria, lower limbs areflexia, decreased vibration sense, muscle weakness in the legs, and positive extensor plantar responses [5–8]. Most patients also have hypertrophic cardiomyopathy, and about one third have diabetes or carbohydrate intolerance [9–12].…”