Given a non-increasing and radially symmetric kernel in L 1 loc (R 2 ; R+), we investigate counterparts of the classical Hardy-Littlewood and Riesz inequalities when the class of admissible domains is the family of polygons with given area and N sides. The latter corresponds to study the polygonal isoperimetric problem in nonlocal version. We prove that, for every N ≥ 3, the regular N -gon is optimal for Hardy-Littlewood inequality. Things go differently for Riesz inequality: while for N = 3 and N = 4 it is known that the regular triangle and the square are optimal, for N ≥ 5 we prove that symmetry or symmetry breaking may occur (i.e. the regular N -gon may be optimal or not), depending on the value of N and on the choice of the kernel.