A completely positive master equation describing quantum dissipation for a Brownian particle is derived starting from microphysical collisions, exploiting a recently introduced approach to subdynamics of a macrosystem. The obtained equation can be cast into Lindblad form with a single generator for each Cartesian direction. Temperature dependent friction and diffusion coefficients for both position and momentum are expressed in terms of the collision cross section. PACS numbers: 05.40.Jc, 03.65.Ca, 03.65.Sq, 05.60.Gg The issue of quantum dissipation, and in particular of quantum Brownian motion, is a long-standing one, which has attracted physicists for decades (for general references see [1,2]) and still seems to be unsolved. Its relevance, however, is growing, especially in connection with decoherence and the relationship between classical and quantum description [3], a field which seems to be now within reach of experimental tests [4]. The classical understanding of the phenomenon is quite well established, relying on Langevin or Fokker-Planck equations obtained by considering a particle typically interacting with a bath of independent oscillators, so that most of the research has been influenced by these results, leading to research for a quantum analog or quantum generalization of these equations. The difficulty lies in the failure of a Hamiltonian description for such systems, so that a clear quantization prescription is missing, and one needs a thoroughly quantum mechanical approach. The most promising results come from the reduced description of a particle interacting with some type of reservoir, thus impinging on techniques and results of open quantum system theory. In this respect the property of complete positivity (CP) has emerged as a very useful and stringent requirement in the study of subdynamics inside quantum mechanics [2,5]. The property of CP asks that the time evolution semigroup U͑t͒ for the irreversible dynamics has the structure U͑t͒ P a K a ͑t͒ K y a ͑t͒ ͑ ͑ ͑ P a K y a ͑t͒K a ͑t͒ 1͒ ͒ ͒ so that, in particular, positivity is preserved, and it originates from the formal requirement that coupling without interaction to an n-level system does not affect positivity. Indeed, CP appears somehow more natural if considered in the context of operations and quantum measurement in which it originally appeared in physics [6]. According to a famous paper by Lindblad [5], under suitable mathematical conditions the property of CP allows for the determination of the general structure of the generators of irreversible time evolutions, even though a thorough understanding of the physical limits of validity of this property is still on its way [7,8], so that satisfaction of CP by itself does not ensure physically meaningful results, and the connection to realistic microphysical models is strongly desirable. In fact recent work has stressed the connection between CP of the time evolution and weak coupling, so that, for example, an uncorrelated statistical operator can consistently be considered as an ini...