On the persistence of mouse urine odour to human observers: a review

Kwak, Jae; Jackson, Marcus; Faranda, Adam; Osada, Kensuke; Tashiro, Takuya; Mori, Kenji; Qian, Ying; Voznessenskaya, Vera V.; Preti, George

doi:10.1002/ffj.3316

Cited by 6 publications

(6 citation statements)

References 109 publications

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“…House mice ( Mus musculu s) excrete large quantities of major urinary proteins (MUPs) that bind and transport hydrophobic ligands, including several volatile pheromones 1–3 . Upon excretion, MUPs slow down the release of volatiles from scent marks 4–8 , which may prolong their attraction and influence on conspecifics. MUPs are often suggested to show high individual diversity and thereby mediate individual and kin recognition 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Regulation of volatile and non-volatile pheromone attractants depends upon male social status

Thoß

Luzynski

Enk

et al. 2019

Sci Rep

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We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of volatile pheromone ligands, and some MUPs exhibit pheromonal properties themselves. We conducted olfactory assays and found that female mice were more attracted to the scent of dominant than subordinate males when they were in estrus. Yet, when male status was controlled, females were not attracted to urine with high MUP concentration, despite being comparable to levels of dominant males. To determine which compounds influence female attraction, we conducted additional analyses and found that dominant males differentially upregulated the excretion of particular MUPs, including the pheromone MUP20 (darcin), and a volatile pheromone that influences female reproductive physiology and behavior. Our findings show that once male house mice become territorial and socially dominant, they upregulate the amount and types of excreted MUPs, which increases the intensities of volatiles and the attractiveness of their urinary scent to sexually receptive females.

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Section: Introductionmentioning

confidence: 99%

Regulation of volatile and non-volatile pheromone attractants depends upon male social status

Thoß

Luzynski

Enk

et al. 2019

Sci Rep

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“…The pungent smell of synanthropic mice species, sensed by humans, is largely determined by sulfur-containing compounds ( Mucignat-Caretta et al 2010 ), particularly, 2- sec -butyl-4,5-dihydrothiazole (SBT) ( Kwak et al 2016 ). SBT is a pheromone stimulating male aggression ( Novotny et al 1985 ), and is also confirmed to be an alarm pheromone in house mice, excreted by both males and females in case of fear ( Brechbühl et al 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Repellent effect of synanthropic house mouse urine odor on small forest mammals

et al. 2022

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In this study we examined an effect of synanthropic house mouse (Mus musculus) urine odor on catching probability of small mammals to live traps. We conducted a series of field experiments in August 2016 and 2017 in natural forest of northwestern Moscow Region (Russia). Small mammals were trapped at two 4-ha fields using capture–mark–recapture technique by setting 200 live traps (100 points, 2 traps per a point) within each field. One trap in each pair was odorless (control) with bait only, while the other one was odor-baited with 20 μL of the urine of synanthropic house mouse. Further analysis was based on the data collected from two rodent species (bank vole Myodes glareolus, Herb field mouse Apodemus uralensis) and three shrew species (common shrew Sorex araneus, Laxmann's shrew S. caecutiens, and Eurasian pygmy shrew S. minutus). As a result, only bank voles significantly avoided odor-baited live traps. Using Generalized Linear Mixed Models, we showed that the choice of a trap by bank voles depended on their age, while the probability of repeated capture to a certain live trap was related to their prior experience. We discuss a possible role of components of synanthropic house mouse urine in population management of exoanthropic small mammals.

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“…Brechbühl et al (2013) identified sulfur-containing alarm pheromone 2sec-butyl-4,5-dihydrothiazole (SBT) in mice, which shares its chemical structure with TMT, a fearful substance isolated from fox feces (Vernet-Maury et al, 1984). SBT is the major mousy odorant and present almost exclusively in male urine; it is not depleted from urine even after repeated headspace or solvent extractions since its majority is tightly bound to the major urinary proteins (MUPs) (Kwak et al, 2016). Interestingly, the results of another recent research indicated that TMT can also negatively affect reproductive outcome in mice (Adduci et al, 2019).…”

Section: Effects In Malesmentioning

confidence: 99%

The effects of predator odors on stress response and reproduction in Norway rats: A review

Klyuchnikova¹,

Struchkov²,

Kvasha³

2020

Ukr J Ecol

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Norway rat (Rattus norvegicus) is an invaluable laboratory model organism as well as one of the most common rodent pest species. The currently used rodenticides have several significant drawbacks: toxicity to humans and non-target species, environmental harm, the development of avoidance reactions and genetic resistance to the applied substances in rat populations. One of the proposed approaches for rodent pest control is based on natural ways, such as predation, which could be emulated by predator scents. In rodents, olfaction plays a key role in danger recognition, especially in detection of potential predator. Predator odors can activate the hypothalamic-pituitary-adrenal (HPA) axis via central nervous system and thus induce the release of stress hormones. A well-documented suppression of reproduction under psychosocial stress appears to be associated with specific interactions of HPA axis and hypothalamus-pituitary-gonadal (HPG) axis. Hereby we review research on the influences of predator chemical cues on stress response and reproduction in Norway rats with a special focus on long lasting and chronic effects. We describe the effects of predator odors of fox (Vulpes vulpes), ferret (Mustela putorius) and domestic cat (Felis catus) in detail. Assessment of reproductive success in rats may be treated as a robust experimental model to evaluate ecologically relevant stress effects of predator odors. Application of this approach could promote development of environmentally friendly methods to control rat population density.

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On the persistence of mouse urine odour to human observers: a review

Cited by 6 publications

References 109 publications

Regulation of volatile and non-volatile pheromone attractants depends upon male social status

Regulation of volatile and non-volatile pheromone attractants depends upon male social status

Repellent effect of synanthropic house mouse urine odor on small forest mammals

The effects of predator odors on stress response and reproduction in Norway rats: A review

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