On the Perfluorocarbon Emulsions of Second Generation

Abstract

For formulation of perfluorocarbon-emulsions (PFC-emulsions) of second generation new perfluorocarbons (F-dimorpholines, F-dipiperidines and F-cyclohexylmorpholine) were synthesized, acting both as oxygen carriers and as interfacial active compounds (IFACs). The stabilizing effect of these IFACs is interpreted and a new theory is introduced. Also new classes of fluorosurfactants were synthesized and tested for biocompatibility. In PFC mixtures compounds of the type RFRH (RF = CmF2m + 1, RH = CnH2n + 1) are acting as IFACs but also as anchor-groups for lipophilic surfactants.

Synthesis and characterization of tri-block fluorinated-n-alkanes

“…Mass spectrometric studies on a series of partially fluorinated alkanes have confirmed their great stability [2]. The main applications for triblock and diblock semifluorinated n-alkanes ranging from biomedical field, as oxygen-carrying agents for blood substitutes [3][4][5][6][7][8], ophthalmology applications [9][10][11][12][13], perfluorocarbons emulsion stabilization [14,15], to applications as solid lubricants.…”

Liquid-assisted ventilation: An alternative respiratory modality

“…19 Synthetic fluorosurfactants have been shown to nearly eliminate PFC/saline interfacial tension. 145 As such, the potential for LAV techniques to minimize pulmonary barotrauma is differ-entiated by the degree to which interfacial tensions are reduced.…”

Fluorocarbon emulsions

“…15-17 'Custom-builtsurfactants are currently being designed with fluoroalkylated chain backbones to give greater fluorocarbon solubility and polar 'head' regions for the aqueous phase based on amino acids, sugars and other biological constituents. 18 In the future, there will be the possibility of modifying the biological response to the emulsion by adapting its emulsifier characteristics. 19,20 Newer fluorocarbons have also incorporated bromide moieties into the structure.…”