On the Paw Oedema Resulting from Subcutaneous Injection of Histamine Liberators in the Rat

Jaques, R.; Riesterer, L.

doi:10.1159/000136117

Cited by 10 publications

(2 citation statements)

References 11 publications

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“…Certain derivatives of corticotrophin, notably alkyl prolyl derivatives, have been shown to be highly potent liberators of histamine derived from mast cells when injected into the peritoneal cavity of the rat [3]. These same polypeptides also cause for mation of a dose-dependent paw oedema when injected under the skin of the hind paw of rats [5],…”

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Mast Cell Count in the Peritoneal Fluid of Rats with Adjuvant-Induced Polyarthritis

Jaques¹,

Majer²,

Riesterer³

et al. 1971

Pharmacology

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Adjuvant-arthritis was induced in rats by means of a subplantar injection (left hind paw) of M. butyricum in paraffine oil and the severity of the disease determined volumetrically on the right, uninjected hind paw when the secondary lesions had reached near-maximal extent. One group of the rats was treated on days 18 to 21 post-adjuvant with hydrocortisone at a daily oral dose of 30 mg/kg and the therapeutic effect assessed in terms of gross paw-oedema changes and of certain parameters mentioned hereafter Using a variety of ‘clinical parameters’ (ESR, albumin/globulin ratio, fibrinogen, fibrinolysis, serum iron and serum copper) as well as other parameters still under experimental evaluation (peritoneal mast cells and ‘inflammatory’ rest cells) it was found that: (a) the ‘clinical parameters’ undergo much the same changes in adjuvant-induced arthritis in the rat as they do in human rheumatoid arthritis; (b) steroid therapy reverses such changes to normal in the rat in a fashion similar to that obtained in man suffering from rheumatoid arthritis and the like; (c) peritoneal mast cell count is low and peritoneal ‘inflammatory’ rest cell count high in full-blown adjuvant-arthritis; (d) a short-term steroid therapy tends to normalise the changes mentioned under (c).

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confidence: 99%

Mast Cell Count in the Peritoneal Fluid of Rats with Adjuvant-Induced Polyarthritis

Jaques¹,

Majer²,

Riesterer³

et al. 1971

Pharmacology

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“…Both forms of oedema, more over, can be inhibited by BOL and methysergide, which suggests that serotonin is also intimately involved in the formation of the oedema induced by the dermatophyte polysaccharides. The fact that tripelennamine had no appreciable inhibitory effect on the swelling can be explained by the relatively low sensi tivity of this particular strain of rats to histamine (Jaques and Riesterer, 1970); the possibility that these dermatophyte polysaccharides may liberate histamine therefore cannot be exluded.…”

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confidence: 92%

Prophlogistic Activity of Water-Soluble Polysaccharides from Dermatophytes in the Rat

Riesterer

Jacques

1974

Pharmacology

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Water-soluble, non-nitrogenous polysaccharides isolated from dermatophytes were tested for prophlogistic activity in the rat. Unlike the type II galactomannans, glucan, mannan and type I galactomannans from various dermatophyte species induce a dose-related swelling of the paw, which follows the same time-course as the oedema caused by dextran. The effect of the dermatophyte polysaccharides can also be antagonized by aminopyrine, tripelennamine, BOL and methysergide. The demonstrable prophlogistic activity of the dermatophyte polysaccharides studies is therefore presumably due to liberation of serotonin and histamine.

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Synthese von lipophil substituierten ACTH‐Peptiden

Brügger

1971

Helvetica Chimica Acta

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On the Paw Oedema Resulting from Subcutaneous Injection of Histamine Liberators in the Rat

Cited by 10 publications

References 11 publications

Mast Cell Count in the Peritoneal Fluid of Rats with Adjuvant-Induced Polyarthritis

Mast Cell Count in the Peritoneal Fluid of Rats with Adjuvant-Induced Polyarthritis

Prophlogistic Activity of Water-Soluble Polysaccharides from Dermatophytes in the Rat

Synthese von lipophil substituierten ACTH‐Peptiden

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