On the pathogenesis of the renoprival hypertension in dogs

Giovannetti, S; A, Bigalli; Balestri, P. L.

doi:10.1007/bf02297034

Cited by 5 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As no direct relation was found between plasma sodium concentration and the hypertension, these observations are compatible with the opinions of other workers who considered expansion of extracellular fluid volume (Leonards & Heisler, 1952;Houck, 1954;Orbison, Peters & Christian, 1956) or blood volume (Giovannetti et al 1965) important in the develop-ment process. The present work suggests that blood volume expansion may be of primary importance, since significant correlation was observed between plasma volume and blood pressure changes over the study period.…”

Section: Conditions Necessary For Renoprival Hypertensionsupporting

confidence: 90%

“…Here again, opinions differed on whether animals kept in sodium and water balance by peritoneal dialysis became hypertensive. Hypertension did not develop in peritoneally dialysed dogs in which salt and water balance was assumed from the lack of significant changes in body weight and serum sodium level after nephrectomy (Leonards & Heisler, 1951;Giovannetti, Bigalli & Balestri, 1965). Muirhead et at.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Haemodynamic and other studies on the renoprival hypertensive rat

Ledingham¹,

Pelling²

1970

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The optimal conditions for the development of hypertension after total nephrectomy were defined in the rat. Under these conditions, haemodynamic changes were then studied before and for 3 days after total nephrectomy in the unanaesthetized animal and compared with mocknephrectomized controls.2. Changes in cardiac output were followed with an electromagnetic flowmeter chronically implanted on the ascending aorta, and mean arterial pressure with an indwelling aortic cannula.3. Haematocrit fell in animals developing hypertension, due to plasma volume expansion. Restriction of administered saline did not reduce the fall in haematocrit without also preventing development of the hypertension.4. Cardiac output and stroke volume increased significantly on the second and third days after nephrectomy. Peripheral resistance remained unchanged and pulse rate tended to fall.5. The increase in cardiac output appeared to be more than could be accounted for by anaemia alone, and it is suggested that plasma volume expansion was partly responsible.6. In another group of rats developing renoprival hypertension a correlation was found between changes in plasma volume and arterial pressure over the three days.7. Renoprival hypertension was accompanied by a slight but significant reduction in oxygen consumption in comparison with the controls. 8. No relationship was found between the changes in blood pressure, and plasma sodium and potassium levels.9. It is concluded that the observed rise in cardiac output associated with renoprival hypertension as induced in this study was not attributable to anaemia nor to a rise in metabolic rate. The implications of this situation are discussed in relation to a theory of the pathogenesis of hypertension and the findings of other workers.

show abstract

Section: Conditions Necessary For Renoprival Hypertensionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%