On the pathogenesis of renal tuberculosis with special reference to the role of local factors

Ureteral obstruction may activate kidney latent tuberculosis. A qualitative study

“…Shabad et al [11] describes the clinical characteristics of patients with UTB in Russia, emphasizing the paramount importance of local factors for the reactivation of renal tuberculosis. Changes in renal urinary flow, i.e., obstruction and decreased renal perfusion, were responsible for this reactivation.…”

“…Shabad also conducted a study with 63 rabbits infected with intravenous or intravesical culture of Mycobacterium tuberculosis (bovine type) with obstruction (ligation or resection) of the left ureter [11] . The kidneys of the rabbits were studied microscopically.…”

New Features in the Pathogenesis of Renal Tuberculosis and Their Significance for its Detection

“…The eliciting factors in the pathogenesis of renal tuberculosis may be di vided into general (tuberculous focis in organism, reduction of resistance of the organism) and local (disturbances of urodynamics) [Shabad, 1971], The present study of our clinical cases has revealed the diminution of the role of general pathogenetic factors. The frequency of a previous or concomitant extraurogenital tuberculosis decreased from 55% (1946)(1947)(1948)(1949)(1950) to 43% (1961-1971; fig.…”

“…However, our exper imental data [Shabad, 1971] showed the presence of urinary obstruction as a caused of the transformation o f 'subclinical' miliary tuberculous foci in the renal cortex into a destructive lesion of the renal medulla, e.g. into'clinical' nephrotuberculosis.…”