On the Origin of Life and Evolution of Living Systems from a World of Biological Membranes

Mittal, Aditya; Bansal, Suneyna; Changani, Anandkumar Madhavjibhai

doi:10.1007/978-3-030-57246-4_8

Cited by 2 publications

(5 citation statements)

References 78 publications

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“…4 Theory on origins of life and biological replication independent of central dogma. A De novo appearance of a micelle and “replication” of the micelle based on law of mass action—a proposal on origins of life and evolution of biological systems from a world of biological membranes (see Mittal et al 2020 for details). B Unilamellar compartments with bilayer formations from similar lipids, binary mixtures, and a heterogenous systems with lipids “third-party” components.…”

Section: Discussionmentioning

confidence: 99%

“…Having discussed common themes on viral fusion mechanisms above, it also pertinent to view fusogenic components of VMPs (e.g., HA2 in HA) as general proteins, instead of a restricted view as only fusion proteins. Recently, it emerged that naturally occurring folded/structured proteins have clear compositional constraints (Mittal et al 2010 , 2020 ; Mittal and Jayaram 2011a , b ). It was also shown that amino acid compositions beyond those constraints are signs of intrinsic disorder in proteins, i.e., lack of specific conformations/structures corresponding to functions (Mittal et al 2021a , b , c ).…”

Section: From Influenza Ha-mediated Membrane Fusion To Other Envelope...mentioning

confidence: 99%

“…Over the years, these models have transformed into a more mosaic view of cell membranes by incorporating localized, often transient, interactions (including those involving peripheral membrane and cytoskeletal proteins along with components of extracellular matrix) resulting in distributions of heterogeneous domains/rafts with different relative mobilities (Jacobson et al 1995 ; Nicolson 2013 ; Almeida 2014 ; Nicolson and Ferreira de Mattos 2021 ). However, the above visualizations of cell membranes, while increasingly attributing active roles to their lipid components, still do not consider those lipids in contexts of origins of life and biological replication (Mittal et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, there are over 100 years of literature on proteins and a little less than 100 years of literature on nucleic acids. Therefore, it is not surprising that exploration of possible biological replication mechanism(s) offered by self-assembling lipid systems in aqueous environments, free from nucleic acids and proteins, is very recent (Mittal et al 2020 ; Steinkühler et al 2020 , 2021 ). However, proper analyses of scientific literature on remodeling in self-assembled membranes and/or vesicular transformations opens up possibilities of “phenotypic” and/or “functional” replication mechanisms in nucleic acid- and protein-free aqueous environments.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling

Mittal

Chauhan

2022

J Membrane Biol

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Biological membrane remodeling is central to living systems. In spite of serving as “containers” of whole-living systems and functioning as dynamic compartments within living systems, biological membranes still find a “blue collar” treatment compared to the “white collar” nucleic acids and proteins in biology. This may be attributable to the fact that scientific literature on biological membrane remodeling is only 50 years old compared to ~ 150 years of literature on proteins and a little less than 100 years on nucleic acids. However, recently, evidence for symbiotic origins of eukaryotic cells from data only on biological membranes was reported. This, coupled with appreciation of reproducible amphiphilic self-assemblies in aqueous environments (mimicking replication), has already initiated discussions on origins of life beyond nucleic acids and proteins. This work presents a comprehensive compilation and meta-analyses of data on self-assembly and vesicular transformations in biological membranes—starting from model membranes to establishment of Influenza Hemagglutinin-mediated membrane fusion as a prototypical remodeling system to a thorough comparison between enveloped mammalian viruses and cellular vesicles. We show that viral membrane fusion proteins, in addition to obeying “stoichiometry-driven protein folding”, have tighter compositional constraints on their amino acid occurrences than general-structured proteins, regardless of type/class. From the perspective of vesicular assemblies and biological membrane remodeling (with and without proteins) we find that cellular vesicles are quite different from viruses. Finally, we propose that in addition to pre-existing thermodynamic frameworks, kinetic considerations in de novo formation of metastable membrane structures with available “third-party” constituents (including proteins) were not only crucial for origins of life but also continue to offer morphological replication and/or functional mechanisms in modern life forms, independent of the central dogma. Graphic Abstract

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Section: Discussionmentioning

confidence: 99%

Section: From Influenza Ha-mediated Membrane Fusion To Other Envelope...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling

Mittal

Chauhan

2022

J Membrane Biol

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“…Lipid membranes can form in micelles or coacervates, thereby representing an evolutionary important step in the development of a typical cell membrane, as found from archaebacteria to eukaryotes [7,51]. Overall, the presence of cell membranes paves the way for many bioelectric phenomena.…”

Section: Protocells To Eukaryotic Cellsmentioning

confidence: 99%

Understanding the Feedback Loops between Energy, Matter and Life

Funk¹

2022

Front. Biosci. (Elite Ed)

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This review gathers recent findings in biophysics that shed light on the biological principle of self-organization, spanning from molecules to more complicated systems with higher information processing capacity. The focus is on "feedback loops" from information and matter to an exchange component with a more fundamental meaning than "cybernetic regulation" and "maintenance of homeostasis". This article proposes that electric and electromagnetic forces are the most important mediators over large distances. Field-like mediation is distinguished from cell-to-cell communication by special electric-or ion-guiding mechanisms that create additional pathways to the "classical" mediators such as nerve conduction or blood flow. Resonance phenomena from phonons and photons in the visible range will be discussed in relation to organelles, cytoskeletal elements and molecules. In this context, the aqueous surrounding of molecules and cells is an important aspect. Many of these phenomena are caused by quantum physics, such as the tunneling of electrons in enzymes or in other coherent working systems. This suggests that quantum information processing is also spread over large-scale areas of an organism.

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On the Origin of Life and Evolution of Living Systems from a World of Biological Membranes

Cited by 2 publications

References 78 publications

Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling

Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling

Understanding the Feedback Loops between Energy, Matter and Life

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