Abstract:Purpose: to identify the origin of confounding angle offset ε_0 in R2 orientation dependence and to propose a novel framework for better characterizing anisotropic R2 in brain white matter (WM).
Methods: Anisotropic (ε) rather than principal diffusivity direction (Φ) was theorized along axon fiber, with ε determined by all eigenvalues and eigenvectors from diffusion tensor. An extra parameter ε_0 was introduced into generalized magic angle effect function to account for any offset in R2 orientation dependence… Show more
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