ON THE ORIGIN AND MIGRATION OF THE SO‐CALLED PRIMORDIAL GERM CELLS IN THE MOUSE AND THE RAT.<sup>1</sup>

Simkins, Cleveland Sylvester

doi:10.1111/j.1463-6395.1923.tb00163.x

Cited by 39 publications

(10 citation statements)

References 23 publications

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“…All these results support the very old Simkins’ hypothesis [ 89 ], recently re-proposed by Mikedis and Downs [ 90 ] (2014), that the so called migratory PGCs are part of a pluripotent stem/progenitor cell pool that exhibits common markers and that, as actually occur in various species (see [ 47 ] and references herein), contribute to various somatic cell lineages and/or even to the stem cell population of adult tissues. Further studies are certainly welcome to clarify these intriguing aspects of the mammalian development.…”

Section: Remarks and Conclusionsupporting

confidence: 85%

To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

Felici

Klinger

Campolo

et al. 2021

IJMS

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In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neoplasias originating from fetal or neonatal germ cells, maintain such dichotomy and can adopt either pluripotent features (embryonal carcinomas) or germness features (seminomas) with a wide range of phenotypes in between these histotypes. Here, we review the basic concepts of cell specification, migration and gonadal colonization of human primordial germ cells (hPGCs) highlighting the analogies of transcriptional/epigenetic programs between these two cell types.

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Section: Remarks and Conclusionsupporting

confidence: 85%

To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

Felici

Klinger

Campolo

et al. 2021

IJMS

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“…This view of mammalian germline development has dominated the field for the past 60 years, silencing early calls by many scientists for an experimental demonstration that so-called extragonadal mammalian PGCs actually contribute to the gonads and are not generalized stem cells that build the conceptus (Simkins, 1923). However, to this day, scientists have not sufficiently demonstrated lineage continuity along the PGC trajectory.…”

Section: Introductionmentioning

confidence: 95%

Mouse Primordial Germ Cells

Mikedis¹,

Downs²

2014

International Review of Cell and Molecular Biology

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“…In the rabbit Buhler (1894) also found only prepubertal ovogenesis. Simkins (1923 and questions the vahdity of the term primordial germ cells, going so far as to state that in the human embryo they are not large wandering cells at all but large liquefied areas surrounding degenerating nuclei.…”

Section: Thusmentioning

confidence: 99%

The eggs of mammals, by Gregory Pincus ...

Pincus¹

1936

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The hving egg was neglected presumably because no technique was developed for preserving it intact in vitro long enough for any extensive experimentation to be performed. Nor did the possibility of experimental manipulation of ova in vivo receive more than passing attention (see Grusdew, 1896; Novak and Eisinger, 1923). Since the pubhcation of Stockard and Papanicolou's (1917) and Long and Evans' (1922) exhaustive accounts of the oestrus cycle of the guinea pig and rat respectively, a new era in the study of sexual physiology has been initiated. Enormous strides have been made in the discovery and purification of the hormones regulating the activities of the genital tracts of mammals. The ovarian control of the various phases of the sex cycles in the female has received exhaustive attention, and the control of gonad function by the anterior pituitary has been investigated in detail. Despite the enormous accumulation of data on the endocrine regulation of the ovarian and oviduct environment of ova, the ova them

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ON THE ORIGIN AND MIGRATION OF THE SO‐CALLED PRIMORDIAL GERM CELLS IN THE MOUSE AND THE RAT.¹

Cited by 39 publications

References 23 publications

To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

Mouse Primordial Germ Cells

The eggs of mammals, by Gregory Pincus ...

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ON THE ORIGIN AND MIGRATION OF THE SO‐CALLED PRIMORDIAL GERM CELLS IN THE MOUSE AND THE RAT.1

Cited by 39 publications

References 23 publications

To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

Mouse Primordial Germ Cells

The eggs of mammals, by Gregory Pincus ...

Contact Info

Product

Resources

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ON THE ORIGIN AND MIGRATION OF THE SO‐CALLED PRIMORDIAL GERM CELLS IN THE MOUSE AND THE RAT.¹