On the Occurrence of a Factor in Human Serum Activating the Specific Agglutination of Sheep Blood Corpuscles.

Waaler, Erik

doi:10.1111/j.1699-0463.1940.tb01475.x

Cited by 527 publications

(66 citation statements)

References 1 publication

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“…[1][2][3] The concept of B-cell-targeting therapy was proposed as early as 1940. 4 However, the approach was not feasible until the invention of monoclonal antibody (mAb) technology in 1975. 5 Thereafter, numerous preclinical and clinical studies have demonstrated that depletion of B-cells can significantly alleviate symptoms of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Ofatumumab

Zhang

2009

mAbs

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Ofatumumab is an anti-CD20 IgG1κ human monoclonal antibody that is being considered by the US Food and Drug Administration and the European Medicines Agency for marketing approval as a treatment for chronic lymphocytic leukemia. The mAb is also being studied as a treatment for lymphoma, rheumatoid arthritis and multiple sclerosis. The candidate targets the same antigen as rituximab, but ofatumumab binds a novel, membrane-proximal epitope, and dissociates from its target at a slower rate compared to rituximab. Ofatumumab might be approved in the US by August 2009.

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Section: Introductionmentioning

confidence: 99%

Ofatumumab

Zhang

2009

mAbs

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“…35 CODEN (USA): UJPRA3 the specificity of RF as a diagnostic marker for RA is low since it is frequently detected in many other conditions such as connective tissue diseases 3,4 .Anticitrullinated peptide antibody (ACPA) target peptides that are post-translationally modified by conversion of arginine to citrulline, occurs primarily in patients of RA and demonstrate a much higher specificity of 95.9% for RA. In addition, ACPA seem to be a better marker of poor prognostic features of progressive joint destruction 5,6 .Mannose-binding lectin (MBL) is a liverderived acute phase protein.…”

Section: Issn: 2456-8058mentioning

confidence: 99%

Seroprevalence of Anti-Mannose Binding Lectin Autoantibodies in Patients With Rheumatoid Arthritis in Sana'a City- Yemen

El-Aghbary

Al-Jaaidi

Al-Moyed

et al. 2018

UJPR

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Rheumatoid arthritis (RA) characterized by synovial inflammation and destruction of cartilage and bone. Until now there is no single test that diagnoses RA, however, several blood tests may suggest the presence of this disease. RA is associated with the presence of a number of autoantibodies as such as rheumatoid factor (RF), anti-cyclic citrullinated peptide (ACPA) and antimannose binding lectin (anti-MBL). This study aimed firstly to investigate the presence of anti-MBL autoantibodies in the sera of RA patients and healthy controls and secondly to determine the diagnostic value of this marker in comparison with the classical RF, C-reactive protein (CRP) and ACPA among RA cases. This case-control study was conducted at four health establishments; two public (Al-Thawra Modern General Hospital and National Center of Central Public Health Laboratories) and two private (University of Science and Technology Hospital and Aulqi Specialized Medical Laboratories) in Sana'a city. Ninety-four individuals were enrolled in this study. Forty-seven persons were clinically diagnosed to have RA by a rheumatologist and 47 healthy subjects without RA were used as controls. Sera were separated and tested for presence of serum anti-MBL autoantibodies, ACPA, RF and CRP by a commercially available enzyme linked immunosorbent assay (ELISA) and latex agglutination technique. Study results showed that the meanSD for the levels of serum anti-MBL autoantibodies among RA cases were 394243 ng/ml which were significantly higher than that recorded among healthy controls (217173 ng/ml). The levels of serum anti-MBL autoantibodies were associated with positive RF and CRP tests (p=.02 and .007 respectively), but not with positive ACPA test (p=.42). The result of this study showed higher levels of serum anti-MBL autoantibodies among RA cases comparing with the healthy controls and reveal an association with positive results for RF and CRP, but not with ACPA. Therefore, the anti-MBL antibody levels may associated with systemic autoimmune diseases and might not exclusive to RA.

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“…Because these antibodies can also be detected in patients with other conditions, they are often not specific. A representative example of such an autoantibody is rheumatoid factor (RF), a well-known, nonspecific autoantibody which is directed to the Fc part of IgG molecules [1]. RF is commonly detected in up to 80% of RA patients, but it is also detected in other diseases, as well as in healthy individuals, especially in the elderly (10-30%) [2], thus lowering its specificity.…”

Section: Introductionmentioning

confidence: 99%

Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis

et al. 2011

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Autoantibodies with the highest specificity for rheumatoid arthritis (RA) are the antibodies directed to citrulline-containing epitopes, so-called anti-citrullinated peptide/protein antibodies (ACPA). During the past decade it became clear that the presence of these antibodies was highly predictive of and specific for RA, and illustrating the importance of ACPA. Therefore, the presence of these antibodies is one of the new American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2010 criteria for RA. Apart from the presence of these antibodies, the composition of this antibody response matures during RA development. This review summarizes the current knowledge of the characteristics of ACPA in RA development.

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On the Occurrence of a Factor in Human Serum Activating the Specific Agglutination of Sheep Blood Corpuscles.

Cited by 527 publications

References 1 publication

Ofatumumab

Ofatumumab

Seroprevalence of Anti-Mannose Binding Lectin Autoantibodies in Patients With Rheumatoid Arthritis in Sana'a City- Yemen

Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis

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