2011
DOI: 10.3389/fnins.2011.00132
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On the Number of Preganglionic Neurons Driving Human Postganglionic Sympathetic Neurons: A Comparison of Modeling and Empirical Data

Abstract: Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose of the present study was to use modeling of spike trains in an attempt to define the number of preganglionic neurons that drive an individual postganglionic neuron. Artificial spike trains were gen… Show more

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Cited by 4 publications
(6 citation statements)
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“…6A). These observations recapitulate aspects of intracellular recordings from vasoconstrictor neurons in anesthetized rats (Bratton et al 2010) and extracellular single-unit recordings from awake, healthy human subjects (Macefield 2011). Indeed, changes in vasoconstrictor sympathetic activity are often characterized in the human microneurography literature in terms of the proportion of cardiac cycles where spikes are generated.…”
Section: Resultssupporting
confidence: 66%
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“…6A). These observations recapitulate aspects of intracellular recordings from vasoconstrictor neurons in anesthetized rats (Bratton et al 2010) and extracellular single-unit recordings from awake, healthy human subjects (Macefield 2011). Indeed, changes in vasoconstrictor sympathetic activity are often characterized in the human microneurography literature in terms of the proportion of cardiac cycles where spikes are generated.…”
Section: Resultssupporting
confidence: 66%
“…We therefore analyzed our data to determine the effect of I h blockade and to compare it with human data from 33 vasoconstrictor neurons [see Fig. 3F in Macefield (2011)]. Each of the 7 cells used to measure synaptic gain had been stimulated with 40 s templates containing 200 cardiac cycles.…”
Section: Resultsmentioning
confidence: 99%
“…However, it may simply be an emergent property of the way in which postganglionic sympathetic neurons are driven. A recent modeling study supports this possibility (Macefield 2011). Model spike trains were generated by one-, two-, or three-model preganglionic neurons, with each model neuron converging onto a single postganglionic neuron, as represented schematically in Fig.…”
Section: Modeling the Firing Properties Of Human Sympathetic Neuronsmentioning
confidence: 99%
“…The bottom trace shows the emulated nerve recording, in which spikes are superimposed on an underlying background noise. The mean interspike interval for each preganglionic neuron was 2,500 Ϯ 5,000 (SD) ms. Reproduced from Macefield (2011). Mean data on the percentage of cardiac intervals in which units were silent (0 spikes) or generated 1, 2, 3, or 4 spikes, firing probability, and mean firing rate.…”
Section: Firing Properties Of Muscle Sympathetic Neurons In Chronic Heart Failure and Respiratory Diseasementioning
confidence: 99%
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