On the Movements of the Excised Ureter of the Dog

Roth, George B.

doi:10.1152/ajplegacy.1917.44.3.275

Cited by 16 publications

(4 citation statements)

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“…Since the first in vitro studies of ureteric function appeared about 1900, no systematic analysis of the influence of acid-base changes upon ureteric smooth muscle contractility has been made, although spontaneous contractions have been studied in various muscle bath solutions ranging from pH 5.6 to 8.4 (Boyarsky and Labay, 1972). Roth (1917) considered that Locke's solution with pH 8.1 to 8.3 was best suited for eliciting maximal spontaneous contractions and rhythmicity of animal ureters. Decreasing pH was associated with a lowering of tone and rhythmicity.…”

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confidence: 99%

Effects of Acid‐base Changes on Human Ureteric Smooth Muscle Contractility

Cole

Fry

Shuttleworth

1990

British Journal of Urology

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Wide fluctuations of both urinary pH and the partial pressure of CO2 (PCO2) occur in normal physiological circumstances and in a variety of pathological conditions. However, the effect of extracellular pH on the contractility of human ureteric muscle has not been clearly defined. This study has established, using a microsuperfusion technique, that an increased superfusate PCO2 increases the magnitude of the phasic contraction to electrical field stimulation. A similar extracellular acidosis induced by alteration of the [HCO3-], at constant [Na+] and free [Ca2+], was without significant effect. Furthermore, when both superfusate PCO2 and [HCO3-] were simultaneously increased at constant pH the contractile response was similar to that when PCO2 alone was raised. These observations suggest that the changes of tension were mediated by intracellular pH changes, providing it is assumed that the ureteric smooth muscle cell membrane is permeable to CO2 but impermeable to H+ and HCO3-. The occurrence of an increase of force in the presence of an acidosis is a highly significant and unusual finding, since it has been assumed that the classical association between acidosis and negative inotropy, seen in cardiac muscle, was also applicable to smooth muscle.

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Effects of Acid‐base Changes on Human Ureteric Smooth Muscle Contractility

Cole

Fry

Shuttleworth

1990

British Journal of Urology

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“…Our observations upon the effects of drugs do not accord with those of other authors working on other animals. Roth (1917) found adrenaline to raise the tone in isolated dogs' ureters, but noted no differences in response from different parts. Satani (1919 a) and Gruber (1930) found the isolated ureter of the pig to respond to adrenaline by an increased rate of contraction, but noted no effect on tone.…”

Section: Discussionmentioning

confidence: 91%

The behaviour of the isolated water‐buffalo ureter

Gould¹,

Hsieh²,

Tinckler³

1955

The Journal of Physiology

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Since Engelmann (1869) described the movements of ureters in laboratory animals it has been generally accepted that urine is carried straight through from the renal pelvis to the bladder with the aid of peristaltic waves. But Fuchs (1936), who observed the passage of urine stained with indigo carmine down the ureters of rabbits, concluded that upon occasion the ureter forms itself into a series of chambers separated by sphincters. Begg (1946) also holds that the existence of a fixed pattern of chambers in the human ureter is confirmed by the appearance of intravenous pyelograms.The ureter has a rich nerve supply and contains ganglia, but much work on nerve stimulation in the intact animal and on drug action on the isolated organ has not established a clear picture of the role played by the central nervous system in regulating ureteric activity. The subject is reviewed by Gruber (1933). Although most authorities accept the idea that the autonomic nervous system influences the ureter, at least one worker (Lapides, 1948) holds that the organ is entirely autonomous, and that its activity depends solely upon the amount of urine secreted by the kidney.This and the following paper report studies designed to determine how the ureter handles urine, and whether or not there is evidence that nervous influences play a role. This paper deals with experiments upon the isolated ureter of the water-buffalo (Bubalus mindorensis), and a second paper with experiments upon the intact ureter of dogs, rabbits and rats. METHODSUreters were obtained from water-buffalo immediately after slaughter and placed in chilled, oxygenated Krebs's bicarbonate solution (NaCl, 0-692%; KCI, 0.0354%; CaC12, 0-0282%; NaHCO3, 0-21%; KH2PO4, 0-0162%; MgSO4.7H20, 0-0294%; glucose, 0.2%) and carried to the laboratory in a Thermos flask. Upon arrival they were cleaned of attached tissue and sections 4-5 cm in length were cut from each end and the middle. These were mounted abreast in a single chamber of 320 ml. capacity within a Palmer's isolated organ-bath, and a thread from each 28 PHYSIO. CXXIX

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“…Atropine has no effect on spontaneous contractions at doses which abolish contractions induced by acetylcholine. Most animals species investigated, including cat (Lucas, 1908), dog (Roth, 1917;Malin et al, 1968), pig (Longrigg, 1974a & b;Muschat, 1929), rabbit (Gosling & Waas, 1971), rat (Finberg & Peart, 1970) and water-buffalo (Gould et al, 1955), have been shown to possess excitatory a-adrenoceptors as in human tissue. Less consistent responses have been found when using f3-adrenoceptorand muscarinic-agonists.…”

Section: Effect Of Drugsmentioning

confidence: 99%

The upper urinary tract.

Longrigg¹

1982

Brit J Clinical Pharma

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On the Movements of the Excised Ureter of the Dog

Cited by 16 publications

References 0 publications

Effects of Acid‐base Changes on Human Ureteric Smooth Muscle Contractility

Effects of Acid‐base Changes on Human Ureteric Smooth Muscle Contractility

The behaviour of the isolated water‐buffalo ureter

The upper urinary tract.

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