This chapter explains the components of Radio Frequency Identification (RFID); the aspects of RFID; the barriers to RFID utilization; the privacy and security issues of RFID; the RFID applications in supply chain management; the RFID applications in the health care industry; the RFID applications in modern business; the Near Field Communication (NFC) in mobile devices; the overview of Mobile Ad-Hoc Network (MANET); the security concern of MANET; and the advanced issues of MANET in the digital age. RFID and MANET become the growing components of Information and Communication Technology (ICT) applications and can be effectively utilized in global operations. The chapter argues that RFID and MANET have the potential to increase the efficiency of operations in various industries, improve asset visibility and traceability, decrease reliance on manual processes, reduce operation costs, and provide useful data for business analytics.