On the mitochondrial aspect of reactive oxygen species action in external magnetic fields

Waliszewski, Przemysław; Skwarek, R.; Jeromin, L.; Manikowski, H.

doi:10.1016/s1011-1344(99)90000-3

Cited by 18 publications

(10 citation statements)

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“…Furthermore, fenretinide reportedly functioned as an antioxidant by reducing 1,1-diphenyl-2-picrylhydrazyl radicals [114,115], suggesting that fenretinide can participate in redox cycling reactions [1,103,114,115]. Collectively, these observations point to the involvement of enzymatic processes, possibly those associated with OXPHOS [103,106,116] and/or 12-LOX activity [80,101], in fenretinide-induced ROS production.…”

Section: Mechanisms Involved In the Initiation Of Apoptosis By Fenretmentioning

confidence: 87%

Mechanisms of fenretinide-induced apoptosis

Hail¹,

2006

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Fenretinide, a synthetic retinoid, has emerged as a promising anticancer agent based on numerous in vitro and animal studies, as well as chemoprevention clinical trials. In vitro observations suggest that the anticancer activity of fenretinide may arise from its ability to induce apoptosis in tumor cells. Diverse signaling molecules including reactive oxygen species, ceramide, and ganglioside GD3 can mediate apoptosis induction by fenretinide in transformed, premalignant, and malignant cells. In many cell types, these signaling intermediates appear to be induced by mechanisms that are independent of retinoic acid receptor activation, and ultimately initiate the intrinsic or mitochondrial-mediated pathway of cell elimination. Numerous investigations conducted during the past 10 years have discovered a great deal about the apoptogenic activity of fenretinide. In this review we explore the mechanisms associated with fenretinide-induced apoptosis and highlight certain mechanistic underpinnings of fenretinide-induced cell death that remain poorly understood and thus warrant further characterization.

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Section: Mechanisms Involved In the Initiation Of Apoptosis By Fenretmentioning

confidence: 87%

Mechanisms of fenretinide-induced apoptosis

Hail¹,

2006

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“…Likewise, enzymes that involve intermediates with radical pairs are sensitive to magnetic fields several orders of magnitude larger than the geomagnetic field (Grissom 1995). Because some retinoids and porphyrins involved in the mitochondrial respiratory chain can form radical pairs, it has been proposed that external magnetic fields of some hundred milliTesla should enhance transfer of electrons and synthesis of reactive oxygen species (ROS) (Waliszewski et al 1999). Additionally, interactions between environmental impacts such as ionising radiation and the corresponding repair mechanisms are known: e.g.…”

Section: Radical-pair Mechanismmentioning

confidence: 99%

Magnetoreception in plants

2005

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This article reviews phenomena of magnetoreception in plants and provides a survey of the relevant literature over the past 80 years. Plants react in a multitude of ways to geomagnetic fields-strong continuous fields as well as alternating magnetic fields. In the past, physiological investigations were pursued in a somewhat unsystematic manner and no biological advantage of any magnetoresponse is immediately obvious. As a result, most studies remain largely on a phenomenological level and are in general characterised by a lack of mechanistic insight, despite the fact that physics provides several theories that serve as paradigms for magnetoreception. Beside ferrimagnetism, which is well proved for bacterial magnetotaxis and for some cases of animal navigation, two further mechanisms for magnetoreception are currently receiving major attention: (1) the "radical-pair mechanism" consisting of the modulation of singlet-triplet interconversion rates of a radical pair by weak magnetic fields, and (2) the "ion cyclotron resonance" mechanism. The latter mechanism centres around the fact that ions should circulate in a plane perpendicular to an external magnetic field with their Lamor frequencies, which can interfere with an alternating electromagnetic field. Both mechanisms provide a theoretical framework for future model-guided investigations in the realm of plant magnetoreception.

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“…Results of the numerous experimental, epidemiological, and theoretical studies are rather controversial, and in all areas so far, no unanimous conclusions have been reached [Repacholi and Greenebaum, 1999]. Several studies have shown that MF exert influence on a large variety of cellular functions, nevertheless the exact mechanism of interaction with living cells is still unclear [Waliszewski et al, 1999;Jajte et al, 2001;Piacentini et al, 2001;Yano et al, 2001].…”

Section: Introductionmentioning

confidence: 99%

Effects of magnetic field on the antioxidant enzyme activities of suspension‐cultured tobacco cells

Sahebjamei

Abdolmaleki

Ghanati

2006

Bioelectromagnetics

123

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Effects of magnetic fields (MFs) on the activities of antioxidant enzymes of suspension-cultured tobacco cells were investigated. Compared with the control cells, exposure of the cells to static MF with the magnitudes of 10 and 30 mT for 5 days, 5 h each day, increased the activity of superoxide dismutase (SOD). In contrast, the activity of the catalase (CAT) and ascorbate peroxidase (APX) was decreased by MF, compared with those of the control cells. Level of lipid peroxidation was also increased by MF. It suggests that MF could deteriorate antioxidant defense system of plant cells.

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On the mitochondrial aspect of reactive oxygen species action in external magnetic fields

Cited by 18 publications

References 0 publications

Mechanisms of fenretinide-induced apoptosis

Mechanisms of fenretinide-induced apoptosis

Magnetoreception in plants

Effects of magnetic field on the antioxidant enzyme activities of suspension‐cultured tobacco cells

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