2009
DOI: 10.1111/j.1753-4887.1998.tb01697.x
|View full text |Cite
|
Sign up to set email alerts
|

On the Methods for Studying the Mechanisms and Bioavailability of Iron

Abstract: Studies of the molecular mechanisms involved in the absorption and bioavailability of iron are important to attempts made worldwide to control the high incidence of iron‐associated disorders. The ultimate objective of these studies is to develop methods that are relevant to iron bioavailability and interactions in humans. However, a comprehensive understanding of the chemical and physiologic mechanisms that influence iron bioavailability is necessary to achieve this goal. Initial studies using in vitro and ani… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2013
2013
2022
2022

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(5 citation statements)
references
References 52 publications
0
5
0
Order By: Relevance
“…The reasons for this observation are not clear. In vitro mineral solubility is a basic index of chemical availability, and it is a function of the cumulative actions of the pH, binding ligands, particle size, and synergistic interactions of enhancers and inhibitors in the food samples (17). Moreover, it is useful for screening large samples and for predicting the trend of mineral availability.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The reasons for this observation are not clear. In vitro mineral solubility is a basic index of chemical availability, and it is a function of the cumulative actions of the pH, binding ligands, particle size, and synergistic interactions of enhancers and inhibitors in the food samples (17). Moreover, it is useful for screening large samples and for predicting the trend of mineral availability.…”
Section: Discussionmentioning
confidence: 99%
“…In vitro mineral solubility is a basic index of chemical availability, and it is a function of the cumulative actions of the pH, binding ligands, particle size, and synergistic interactions of enhancers and inhibitors in the food samples. 17 Moreover, it is useful for screening large samples and for predicting the trend of mineral availability. Whereas iron solubility, in particular, has been reported to correlate positively with absorption, discrepancies of lack of correlation of in vitro with in vivo bioavailability studies are also evident in the literature.…”
Section: ■ Discussionmentioning
confidence: 99%
“…By contrast, the solubilities of Ca and Mn in the flour‐meat mixtures were lower than the sole flour (Table 2). Notably, the mineral solubility is influenced by the synergistic interactions of inhibitors or enhancers in food, the particle size, pH value, and the degree of mineral encapsulation (Latunde‐Dada et al., 2014, 1998). For instance, phytic acid or polyphenols from plant‐based foods negatively affected the mineral solubility by creating insoluble mineral complexes that appeared to be hard degraded by enzymes (Etcheverry et al., 2012).…”
Section: Resultsmentioning
confidence: 99%
“…Iron uptake by the apical surface is transported to the basolateral pole in a process that is saturable and facilitated not only by iron ionization, but also by the iron status of the cell. In addition, Caco-2 cells resynthesize three important proteins involved in iron metabolism, apotransferrin, transferrin and ferritin (Latunde-Dada et al, 1998).…”
Section: Common Methods Used In Fe Metabolismmentioning
confidence: 99%
“…E-mail: javierdc@ugr.es A variety of experimental models have been used in studies related to iron through the time (Latunde-Dada et al, 1998;Srigiridhar and Nair, 2000;Morgan and Oates, 2002;Troost et al, 2003;Nagababu et al, 2008;Quintero et al, 2008;Jin et al, 2009;Latunde-Dada, 2009). Nevertheless, in vitro systems or animal models have different iron metabolism behaviour when compared with humans (Latunde-Dada et al, 1998;Vaghefi et al, 2005;Patterson et al, 2008;Quintero et al, 2008). Studies related to iron involve different procedures including isotopic techniques, simulated enzymatic gastrointestinal digestion or hemoglobin (Hb) depletion-repletion (Srigiridhar and Nair, 2000;Beach et al, 2003;Vaghefi et al, 2005;Kolachala et al, 2007;Quintero et al, 2008).…”
Section: Introductionmentioning
confidence: 99%