On the mechanisms of surface microdischarge plasma treatment of onychomycosis: Penetration, uptake, and chemical reactions

Xiong, Zilan; Huang, Renjie; Zhu, Yu; Luo, Kang; Li, Mengqi; Zou, Zhenping; Han, Rui

doi:10.1002/ppap.202000204

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…In recent years, air plasma produced by discharge at atmospheric pressure has been widely applied in many fields, such as material processing [1], biomedicine [2], and plasma-assisted combustion [3], which has attracted enormous attention. Gas discharge at atmospheric pressure exists in many forms, including glow, spark, and corona discharges [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Study on characteristics of acoustic signals generated by different DC discharge modes

Xiong¹,

Wang²,

Li³

2023

Plasma Sci. Technol.

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Acoustic signals contain rich discharge information. In this study, the acoustic signal characteristics of transient glow, spark, and glow discharges generated through DC pin-pin discharge were investigated. The signals were analyzed in the time, frequency, and time-frequency domains, and the correlation between the electric and the acoustic signal was studied statistically. The results show that glow discharge does not produce measurable sound signals. For the other modes, with the decrease in the discharge gap, the amplitude of the acoustic signal increases sharply with mode transformation, the short-time average energy becomes higher, and the frequency components are more abundant. Meanwhile, the current pulse and sound pressure pulse have a one-to-one relationship in the transient glow and spark regimes, and they are positively correlated in amplitude. A brief theoretical analysis of the mechanism of plasma sound and the trends of signals in different modes is presented. Essentially, the change in the discharge energy is closely related to the sound generation of the plasma.

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Section: Introductionmentioning

confidence: 99%

Study on characteristics of acoustic signals generated by different DC discharge modes

Xiong¹,

Wang²,

Li³

2023

Plasma Sci. Technol.

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“…Surface microdischarge (SMD) has received significant attention because of its broad application prospects in food preservation [1,2], agriculture [3,4], material processing [5,6], and biomedicine [7,8]. SMD is a simple process that allows direct discharge in air without the use of a specific background gas; furthermore, it offers the advantages of low cost, high primarily completed using equipment such as a spectrometer, ozone detectors, and nitrogen oxide detectors.…”

Section: Introductionmentioning

confidence: 99%

Operation-mode recognition of surface microdischarge based on visible image and deep learning

Chen¹,

Peng²,

Xiong³

2022

J. Phys. D: Appl. Phys.

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Discharging images contain useful information regarding the operation mode of surface microdischarge (SMD). To solve the shortcomings of low efficiency, high cost, and long operation time of existing SMD operation-mode recognition methods, a convolutional neural network (CNN) based on deep learning is introduced herein. The visible image library of SMD at different applied voltages, dielectric sheets with different dielectric constants, and dielectric sheets with different thicknesses and exposure times are constructed using a digital camera. The typical structure of a CNN is discussed, and the hyperparameters, including the number of network layers, convolution kernel size, number of neurons in the fully connected layer, and activation function type that affect the recognition accuracy of the CNN are investigated. The optimal structure of the CNN for the SMD operation-mode recognition is obtained via training. The recognition accuracy of the CNN is compared with those of three traditional machine learning methods: support vector machine (SVM), decision tree (DT), and random forest (RF). Test results show that the recognition accuracy based on the CNN is 99.745%, which is better than those of the SVM, DT, and RF. Finally, an SMD operation-mode online recognition method based on the CNN is proposed.

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“…Under certain conditions, this technology can generate a large-volume, uniform, and highly active nonequilibrium plasma. It is currently a research hotspot in the field of discharge and plasma [1][2][3][4][5][6][7]. Further, the development of pulse power technology has increased the wide utilization of atmospheric-pressure pulsed dielectric barrier discharge (PDBD) employing repetitive pulse voltage as the excitation source.…”

Section: Introductionmentioning

confidence: 99%

Sterilization mechanism of helium/helium–oxygen atmospheric-pressure pulsed dielectric barrier discharge on membrane surface

Chen

Li²,

Li³

et al. 2022

Plasma Sci. Technol.

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Pulsed dielectric barrier discharge (PDBD) exhibits several applications in different fields; however, the interaction of its components with its substance remains a key issue. In this study, we employed experimental and numerical modeling to investigate the interactions between different PDBD components and substances in pure helium and a helium–oxygen mixture. A membrane comprising a Staphylococcus aureus strain was utilized as the treatment object to demonstrate the trace actions of the evolutions and distributions of certain components on the surface of the substance. The results revealed that the shapes and sizes of the discharging area and inhibition zone differed in both groups. Under a pure helium condition, a discharge layer existed along the membrane surface, lying beside the main discharging channel within the electrode area. Further, an annulus inhibition zone was formed at the outer edge of the electrode in the pure helium group at 30 s and 1 min, and this zone extended to a solid circle at 2 min with a radius that was ~50% larger than that of the electrode radius. Nevertheless, the discharging channel and inhibition zone in the helium–oxygen mixture were constrained inside the electrode area without forming any annulus. A two-dimensional symmetrical model was developed with COMSOL to simulate the spatiotemporal distributions of different particles over the membrane surface, and the result demonstrated that the main components, which formed the annulus inhibition zone under the pure helium condition, contributed to the high concentration of the He+ annulus that was formed at the outer edge of the electrode. Moreover, O+ and O2+ were the main components that killed the bacteria under the helium–oxygen mixture conditions.

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On the mechanisms of surface microdischarge plasma treatment of onychomycosis: Penetration, uptake, and chemical reactions

Cited by 8 publications

References 36 publications

Study on characteristics of acoustic signals generated by different DC discharge modes

Study on characteristics of acoustic signals generated by different DC discharge modes

Operation-mode recognition of surface microdischarge based on visible image and deep learning

Sterilization mechanism of helium/helium–oxygen atmospheric-pressure pulsed dielectric barrier discharge on membrane surface

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