On the mechanism of the hypertrophy of the retrolingual glands of the rat induced by incisor amputations

Houssay, Alberto B.; Ugarte, CE

doi:10.1016/0003-9969(69)90021-1

Cited by 16 publications

(6 citation statements)

References 9 publications

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“…In contrast, in the sublingual glands, the weights and contents of RNA were markedly decreased with atropine. These results confirm the findings of others (Houssay et al, 1969;Houssay, 1966) that submandibular enlargement is dependent on the integrity of both the sympathetic and the parasympathetic nerve supply, while sublingual enlargement is only under parasympathetic control.…”

Section: Discussionsupporting

confidence: 94%

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

et al. 1988

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The effects of upper incisor separation on the submandibular and sublingual glands of rats were examined biochemically, immunohistologically, and radio-immunologically during 28 days of treatment. Lateral separation of the upper incisors by application of force from an orthodontic appliance caused significant enlargement of the sublingual and submandibular glands of rats by three and seven days, respectively, after the beginning of the orthodontic treatment. This enlargement was followed by a significant increase of both RNA and DNA content, with some evidence of hyperplasia and hypertrophy. The enlargement was also associated with a significant increase of substance P at early stages after treatment, suggesting the involvement of the sensory nerves. These changes were largely inhibited by phenoxybenzamine, an alpha-adrenergic blocker, but not by atropine or morphine. Wet weights and RNA contents of the sublingual glands were markedly reduced by atropine. In comparison with control animals, the enlarged submandibular glands of rats subjected to orthodontic treatment secreted additional proteins identical with those secreted by glands enlarged by chronic administration of isoproterenol. In addition, chemical sympathectomy with 6-hydroxydopamine and phenoxybenzamine stimulated the synthesis of these abnormal proteins, but atropine and morphine did not. In contrast, protease activities in the convoluted granular tubule cells in the submandibular glands were increasingly reduced after treatment, as seen in rats subjected to chronic treatment with isoproterenol. However, the submandibular and sublingual glands completely recovered after removal of the orthodontic appliance.

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Section: Discussionsupporting

confidence: 94%

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

et al. 1988

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“…The report of Wells and Munson (1959) even showed a negative relationship between the weight gain and the number of amputations. The decrease in weight gain has been attributed to the diminished feeding efficiency and food intake (Houssay andAlvarez Ugarte 1969, Chiba et al 1981). In some other studies, it was found that the rats actually had a weight loss after repeated shortening of the incisors (Houssay andUgarte 1969, Yagil andBarka 1986).…”

Section: Discussionmentioning

confidence: 99%

A comparison between a conventional optical method and image-analysis for measuring the unimpeded eruption rate of the rat mandibular incisor

Lee

Law

King

et al. 2002

Archives of Oral Biology

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The impeded/unimpeded eruption rates of the rat incisor have been much studied. The most commonly used optical microscopic method, which has inherent weaknesses, was compared here with an image-analysis method to measure the eruption rate of the mandibular incisor. The study also evaluated the incisal edge as a reference point for the measurement of the unimpeded eruption rate, and the frequency of shortening the mandibular incisor. The image-analysis method was found to be a simple and reliable technique that could replace the optical method. There was no significant difference between the data from the two methods; their kappa coefficients were similar at the 0.99 level. It was concluded that shortening the incisor in the measurement of the unimpeded eruption rate should be done at least every 48 h, and that the incisal edge of the shortened incisor can be used as the reference point for that measurement.

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“…It is important to emphasize that the biologic model used in the present investigation presents some differences in relation to those described elsewhere 14,27,33 . We have used unilateral amputation of the left lower incisor tooth instead of bilateral AMPT.…”

Section: Discussionmentioning

confidence: 92%

“…It is well known that the salivary glands develop atrophy when submitted to parasympathetic denervation, however this phenomenon is reversed by AMPT of the lower incisor teeth 14,27,33 . In our study, the AMPT was not able to reverse the atrophy of SMG caused by parasympathectomy.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, non denervated glands showed an increase in the acini volume density, while no alterations were observed in the sympathectomized animals. Therefore, parasympathetic innervation responds for the trophism of SMG, and the development of sialadenosis is dependent upon the integrity of the autonomic nervous system 14,15 . The enlargement of salivary glands caused by AMPT leads to hypertrophy and hyperplasia 4,26 .…”

Section: Discussionmentioning

confidence: 99%

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Effect of unilateral incisor tooth amputation on the glucose metabolism in submandibular glands of rats following sympathetic and parasympathetic denervation

Almeida-De-Faria

Bauer

Nicolau³

2000

Pesqui. Odontol. Bras.

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The autonomic nervous system is of major importance in the regulation of physiological functions of the salivary glands, including the sialadenotrophic process. It is well known that the secretory function as well as other functions in the salivary glands depend upon the energy produced in the gland. The acini volume density, some enzymes of the glucose metabolism, such as hexokinase, phosphofructokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase and lactate dehydrogenase were evaluated following sympathetic and parasympathetic denervation of submandibular glands of rats, submitted to unilateral incisor amputation, five days after denervation. Sympathectomized glands submitted to amputation showed a reduction in the activity of hexokinase and phosphofructokinase-1, varying from 27.5 to 36.7 % for hexokinase and from 22.8 to 38.4 % for phosphofructokinase-1. Although no variation was observed in the enzymatic activity of parasympathectomized animals, the acini volume density showed a significant decrease.

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On the mechanism of the hypertrophy of the retrolingual glands of the rat induced by incisor amputations

Cited by 16 publications

References 9 publications

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

A comparison between a conventional optical method and image-analysis for measuring the unimpeded eruption rate of the rat mandibular incisor

Effect of unilateral incisor tooth amputation on the glucose metabolism in submandibular glands of rats following sympathetic and parasympathetic denervation

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