On the mechanism of the adjuvant effect of Bordetella pertussis vaccine

Reed, Charles E.; Benner, Marilen; Lockey, Stephen D.; Enta, T; Makino, Sohei; Carr, Robert H.

doi:10.1016/0091-6749(72)90111-x

Cited by 23 publications

(11 citation statements)

References 15 publications

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“…This is probably due to the presence of transplacentally acquired antibody to PT. PT is a strong adjuvant in several immunologic systems in several animals and humans (14,15,190,235,246,452,453,456,553,561,573,575,578,600,610,649,699,745,746,801,804). This adjuvancy in the experimental-animal model is associated with enhancement of serum antibody responses to other antigens, increased cellular immune responses to various protein antigens, contribution to hyperacute experimental autoallergic encephalomyelitis, and increased anaphylactic sensitivity.…”

Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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“…Reed et al [12] found a significantly increased antibody production, including reagins, in rats treated with /5-adrenergic blocking drugs, compared with animals treated with isoprenaline, a /5-receptor stimulant. Chronic /5-adrenergic blockade with propranolol enhanced IgE antibody formation in mice [4].…”

Section: Introductionmentioning

confidence: 99%

Influence of Adrenergic Drugs on IgE Production

Pauwels¹,

Bazin²,

Platteau³

et al. 1980

Int Arch Allergy Immunol

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The influence of some adrenergic drugs (fenoterol, salbutamol, terbutaline as stimulant; propranolol as blocker) on IgE production in the rat was investigated. The drugs were administered orally, mixed in the food. The stimulant drugs caused a significant decrease of total serum IgE but had no influence on the specific IgE antibody response. The beta adrenergic blocker caused a significant increase of total serum IgE but also had no influence on specific IgE. The effect of terbutaline was blocked by propranolol. No influence of these adrenergic drugs on IgA and IgM levels was observed.

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“…Experimental efforts to evoke an IgE an tibody response in rodents by the adminis tration of propranolol at the time of immu nization have been unsuccessful, although both total and homocytotropic antibody for mation are increased if the antigen is given with an adjuvant [2,26]. In the present study, a separate adjuvant was not required to initiate production of IgE antibody.…”

Section: Discussionmentioning

confidence: 64%

“…The initia tion and maintenance of IgE antibody syn thesis in the rabbit appears to be influenced by a number of factors, including the na ture, dose and route of administration of an tigen, the use of adjuvants, the formation of antibodies of other immunoglobulin classes and age and genetic capacity to produce IgE antibody [6,24,25,27,[29][30][31][32][33]39 influenced by agents which alter the activity of the adenylate-cyclase-coupled yî-adrenergic receptor [2,22,26], This report de scribes the effects of two adrenergic antago nists on antibody formation in the rabbit.…”

mentioning

confidence: 99%

Enhancement of IgE Antibody Formation in the Rabbit by Adrenergic Antagonists

Homer¹,

Cain²

1979

Int Arch Allergy Immunol

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The effects of adrenergic antagonists on the humoral immune response of rabbits to egg albumin was studied. Propranolol, a β-adrenergic antagonist, when administered at a dosage of 20 mg/kg of body weight, enhanced both passive hemagglutinating and IgE (passive cutaneous anaphylaxis) antibody formation. Phenoxybenzamine, an α-antagonist, at 0.4–40 mg/kg had a similar adjuvant effect. A marked delay in the immune response was noted with high dosages of phenoxybenzamine. Possible mechanisms of the adjuvant effects of these drugs are discussed.

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On the mechanism of the adjuvant effect of Bordetella pertussis vaccine

Cited by 23 publications

References 15 publications

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Influence of Adrenergic Drugs on IgE Production

Enhancement of IgE Antibody Formation in the Rabbit by Adrenergic Antagonists

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