On the mechanism of the electrogenic sodium pump dependence of membrane chemosensitivity

Ayrapetyan, S. N.; Arvanov, Viktor L.

doi:10.1016/0300-9629(79)90592-9

Cited by 29 publications

(22 citation statements)

References 4 publications

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“…Our early works showed that membrane proteins having enzymatic, receptor and channel-forming properties can be in functionally active and inactive (reserve) states, the ratio of which is changed depending on cell hydration [1]. Cell swelling (membrane unpacking), leads to the increase of functionally active membrane receptors' [2,3], membrane enzyme molecules' [4] and ionic channels' number in membrane [5], while its dehydration (membrane packing) has an opposite effect. On the basis of these data cell swelling can be considered as primary messenger switching on intracellular signaling system through which the protective reaction of cells is realized.…”

Section: Introductionmentioning

confidence: 99%

Age-Dependent Brain Tissue Hydration, Ca Exchange and their Dose- Dependent Ouabain Sensitivity

Ayrapetyan¹

2012

JBB

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Section: Introductionmentioning

confidence: 99%

Age-Dependent Brain Tissue Hydration, Ca Exchange and their Dose- Dependent Ouabain Sensitivity

Ayrapetyan¹

2012

JBB

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“…The increase of cell hydration stimulates the metabolic reactions by activation of intracellular macromolecules [31] and membrane proteins, having enzymes [27], receptors [32] and ionic channel forming properties [33] by surface-dependent changes of cell membrane. It is known that in living cells intracellular osmotic pressure exceeds the extracellular one.…”

Section: Discussionmentioning

confidence: 99%

Non-thermal microwave radiation-induced brain tissue dehydration as a potential factor for brain functional impairment

Nikoghosyan

Heqimyan

Ayrapetyan

2016

IJBAS

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Based on our previous finding that metabolically controlled cell hydration is sensitive to the changes of physicochemical properties of cell aqua medium, which take place upon the effect of weak physical signals, including microwaves with non-thermal intensity (NT MW), it has been hypothesized that cell aqua medium serves as a primary target for NT MW effect on brain tissue. To elucidate the nature of the metabolic pathway through which the effect of NT MW-induced changes of physicochemical properties of cell aqua medium modulate cell hydration, the effects of intraperitoneal (IP) injection of PS treated by NT MW on brain tissue hydration, 45 Ca 2+ uptake, ] i), it is considered as a potential factor leading to the brain functional impairment, especially when brain metabolic activity is depressed (e.g. during aging).

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“…Our previous investigations showed 2 functionally different states of membrane proteins, active and inactive (reserve) 2 ISRN Biophysics in eukaryotic cells [12]. The ratio of these active and inactive molecules could be changed by the modulation of cell hydration [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…The ratio of these active and inactive molecules could be changed by the modulation of cell hydration [12][13][14]. It was also shown, that metabolic poisons cause cell hydration [15] resulting in the increase of the number of functionally active receptors in the membrane [12]. On the one hand, CO 2 , as a strong metabolic poison, that leads to the increase of cell hydration, could serve as a potential factor able to elevate membrane sensitivity to H 2 O 2 or/and Ca(ClO) 2 of microbes.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dioxide as a Microbial Toxicity Enhancer of Some Antibacterial Agents: A New Potential Water Purification Tool

2012

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The aim of current paper was to investigate the possibility of increasing the toxicity of calcium hypochlorite (Ca(ClO)2) and hydrogen peroxide (H2O2) onEscherichia coli K-12by preliminary enrichment of culture media by carbon dioxide (CO2). For this purpose, the microbes sensitivity to H2O2or/and Ca(ClO)2at normal and CO2-enriched medium was studied by spectrophotometric, radioisotopic, and electronmicroscopic methods. Ten-minute preincubation in CO2-enriched medium enhanced the toxic effect of both H2O2or/and Ca(ClO)2on bacteria as a result of induced growth inhibition, compared to no-CO2enriched group. Additionally, changes in cell morphology and proliferation were observed. It was demonstrated that the preliminary incubation of microbes in CO2-enriched culture media in nonsupercritical concentration elevate the toxic effect of H2O2or/and Ca(ClO)2on microbes. This can serve as a novel, effective, inexpensive, and environmentally friendly approach for water purification from bacteria, further improving the protection of the environment and human health.

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On the mechanism of the electrogenic sodium pump dependence of membrane chemosensitivity

Cited by 29 publications

References 4 publications

Age-Dependent Brain Tissue Hydration, Ca Exchange and their Dose- Dependent Ouabain Sensitivity

Age-Dependent Brain Tissue Hydration, Ca Exchange and their Dose- Dependent Ouabain Sensitivity

Non-thermal microwave radiation-induced brain tissue dehydration as a potential factor for brain functional impairment

Carbon Dioxide as a Microbial Toxicity Enhancer of Some Antibacterial Agents: A New Potential Water Purification Tool

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