On the mechanism of rhabdomyolysis in potassium depletion

Knöchel, James P.; Schlein, Edward

doi:10.1172/jci106976

Cited by 245 publications

(94 citation statements)

References 19 publications

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“…Potassium release from muscle cells normally mediates vasodilation and an appropriate increase in muscle blood flow. However, decreased potassium release from muscle cells due to hypokalemia can decrease the blood flow to muscles, leading to ischemic rhabdomyolysis (11). In the present case, severe hypokalemia could have been the cause of rhabdomyolysis; however there is a good possibility that it was the result of resuscitation and defibrillations, which can also increase CPK and LDH.…”

Section: Discussionmentioning

confidence: 59%

Severe Hypokalemia and Thyrotoxic Paralysis from Painless Thyroiditis Complicated by Life-threatening Polymorphic Ventricular Tachycardia and Rhabdomyolysis

et al. 2014

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A 61-year-old man presented with lower extremity paralysis and severe hypokalemia. His thyroid function test showed thyrotoxicosis. Despite attempts to correct his hypokalemia, he developed pulseless polymorphic ventricular tachycardia two hours later. He was successfully resuscitated after defibrillation. We performed continuous venovenous hemodiafiltration for 10 days due to acute kidney injury and rhabdomyolysis. We observed life-threatening polymorphic ventricular tachycardia requiring urgent defibrillation, as well as rhabdomyolysis requiring dialysis during the transient thyrotoxic phase of painless thyroiditis. Pay attention to the possibility of the development of life-threatening ventricular tachycardia associated with hypokalemia in the setting of thyroiditis and thyrotoxic paralysis.

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Section: Discussionmentioning

confidence: 59%

Severe Hypokalemia and Thyrotoxic Paralysis from Painless Thyroiditis Complicated by Life-threatening Polymorphic Ventricular Tachycardia and Rhabdomyolysis

et al. 2014

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“…Hypokalemia also leads to diminished muscle perfusion as potassium is a vasodilator and mediates hyperemic response during exercise, resulting in cramps, ischemic necrosis, and rhabdomyolysis. 6 Second, the Na-Ca exchange pumps are disturbed due to the decreased extracellular sodium. This leads to increased intracellular calcium levels because of reduced extracellular sodium to be exchanged causing the cell death by the release of lipase and proteases.…”

Section: Discussionmentioning

confidence: 99%

Addisonian crisis complicated by rhabdomyolysis and acute kidney injury

et al. 2017

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“…This can be explained by the rhabdomyolysis. The mechanism behind hypokalaemic rhabdomyolysis is not fully understood, but it is believed that decreased potassium levels causes vasoconstrictions and ischemia in the muscle cells, which can lead to muscle necrosis and rhabdomyolysis [5].…”

Section: Discussionmentioning

confidence: 99%

Liquorice-Induced Hypokalaemia and Rhabdomyolysis

Kronborg-White

2013

J Endocrinol Metab

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This is a case report of a 60-year-old man who was admitted at the emergency department with tetra paresis, severe hypokalaemia, rhabdomyolysis and hypertension. The cause could have been hyperaldosteronism, but was found to be liquorice intoxication. Liquorice is both available and widely used in both the confectionary and medical sectors. It has glucocorticoid and mineralocorticoid properties, but can, if consuming too much, lead to an acquired form of apparent mineralocorticoid excess syndrome which causes hypokalaemia, hypernatremia, oedema, hypertension, metabolic alkalosis and low plasma renin and aldosterone levels. In this case, the patient developed rhabdomyolysis because of his hypokalaemia. It is believed that potassium depletion causes ischemia in the muscle cells and it therefore can lead to muscle cramps and necrosis.

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On the mechanism of rhabdomyolysis in potassium depletion

Cited by 245 publications

References 19 publications

Severe Hypokalemia and Thyrotoxic Paralysis from Painless Thyroiditis Complicated by Life-threatening Polymorphic Ventricular Tachycardia and Rhabdomyolysis

Severe Hypokalemia and Thyrotoxic Paralysis from Painless Thyroiditis Complicated by Life-threatening Polymorphic Ventricular Tachycardia and Rhabdomyolysis

Addisonian crisis complicated by rhabdomyolysis and acute kidney injury

Liquorice-Induced Hypokalaemia and Rhabdomyolysis

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