On the mechanism of prostaglandin F2α-induced abortion in hamsters

Giannina, T.; Butler, M. C.; Sawyer, Wilbur K.; Steinetz, Bernard G.

doi:10.1016/0010-7824(74)90062-6

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…The potent progestin ENT was administered concomitantly to reduce the likelihood of prostaglandin-induced abortion. Previous work had shown that ENT did not interfere with the RIA of serum progesterone [34,351. Injection of the PGF 2 .…”

Section: Discussionmentioning

confidence: 98%

Patterns of Relaxin and Steroids in the Reproductive Cycle of the Common Marmoset (Callithrix Jacchus): Effects of Prostaglandin F2α on Relaxin and Progesterone Secretion during Pregnancy

Steinetz¹,

Randolph²,

Mahoney³

1995

Biology of Reproduction

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We measured the concentrations of relaxin (Rlx), progesterone, and estradiol-17 beta in serum samples obtained twice or three times weekly from marmosets during the estrous cycle and pregnancy. The cyclic patterns and concentrations of progesterone and estradiol-17 beta were similar to those reported by previous investigators. Rlx was not detected in individual serum samples ( < 0.62-1.25 ng/ml) obtained from nonpregnant marmosets. However, pooling of luteal serum from all animals permitted assay of much larger volumes of serum (0.4 ml vs. 0.1 ml), and a concentration of about 1 ng/ml was detected. Rlx was first detected in serum in the second or third week of the 21-wk marmoset pregnancy, rose to a peak during Weeks 10-14, and then declined slowly as the time of parturition approached. The pattern of Rlx was unlike that observed during pregnancy in Old World monkeys, chimpanzees, or women, and resembled, instead, that seen in rodents, carnivores, and equids. Progesterone and estradiol-17 beta likewise increased throughout pregnancy, and their patterns were similar to those previously described for marmosets by other investigators. The concentrations of the steroids and Rlx in serum of pregnant marmosets was 10-fold or more higher than those found in Old World monkeys, baboons, chimpanzees, or women. Spontaneous abortions in two of the marmosets were accompanied by precipitous falls in serum levels of progesterone, estradiol-17 beta, and Rlx. Following s.c. injection of the luteolytic agent prostaglandin F2 alpha (PGF2 alpha) into two marmosets at midpregnancy, serum progesterone and Rlx fell to low levels. These animals received a progestin, 17 alpha-ethyl-19-nortesterone, to preclude abortion. Serum progesterone rose again, but serum Rlx remained low for the duration of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 98%

Patterns of Relaxin and Steroids in the Reproductive Cycle of the Common Marmoset (Callithrix Jacchus): Effects of Prostaglandin F2α on Relaxin and Progesterone Secretion during Pregnancy

Steinetz¹,

Randolph²,

Mahoney³

1995

Biology of Reproduction

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“…In the pregnant heifer neither decrease in progesterone nor increase in the prostaglandin metabolite level was seen. Exogenous PGF2a has been shown to be luteolytic in many species; in the rat (Pharriss 8c Wyngarden 1969;Bishop 8c Flack 1973;Strauss 8c Stambaugh 1973;Fuchs et al 1974), guinea pig (Blatchley 8c Donovan 1969;Chaichareon et al 1974), hamster (Johnston 8c Hunter 1970;Labhsetwar 1971;Gutknecht et al 1971;Giannina et al 1974), rabbit (Gutknecht et al 1969;Pharriss 1970;Abel et al 1973;Bruce 8c Hillier 1974), gerbil (Chaichareon et al 1974), sheep (McCracken et al 1970; Barrett et al 1971;Chamley et al 1972;Douglas 8c Ginther 1973;Goding 1974), goat , swine (Gleeson 1974;Hallford et al 1974), horse (Douglas 8c Ginther 1972Noden et al 1974;Oxender et al 1974) and cattle (Rowson et al 1972;Lauderdale 1972;Louis et al 1972Louis et al , 1973Shelton 1973;Wishart 1973;King 8c Robertsson 1974;Lauderdale 1974;Lauderdale et al 1974;Oxender et al 1974;Roche 1974;Edqvist et al 1975;Hafs et al 1975).…”

mentioning

confidence: 97%

Blood Levels of Progesterone and 15-Keto-13,14-Dihydro-Prostaglandin F2 During the Normal Oestrous Cycle and Early Pregnancy in Heifers

Kindahl

Edqvist

Bane

et al. 1976

European Journal of Endocrinology

152

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Peripheral plasma levels of progesterone1) and 15-keto-13,14-dihydroprostaglandin F2\g=a\ were measured during the normal oestrous cycle in three heifers. Before the experiment the animals received an infusion each of different amounts of prostaglandin F2\g=a\ to estimate the conversion of this compound into the main plasma metabolite, 15-keto-13,14-dihydroPGF2a. The experimental period was initiated by heat synchronization with 25 mg prostaglandin F2a given intramuscularly. Daily blood samples were collected from the jugular vein until day 14 of the oestrous cycle and subsequently every third hour until heat occurred. During this heat the three heifers were mated, and blood samples were collected in the same way during the following cycle and over the next expected heat. Pregnancy occurred in one of the animals. High levels of 15-keto-13,14\x=req-\ I) The following trivial names are used:Progesterone: 4-pregnene-3,20-dione.Prostaglandin F2(( (PGF2r/): 9ot,lla,15-trihydroxyprosta-5,13-dienoic acid. 15-keto-13,14-dihydro-prostaglandin F2a: 9a,lla-dihydroxy-15-ketoprost-5-enoic acid.

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“…This may be explained by the short period between treatment and removal of CL for the present study. Giannina, Butler, Sawyer & Steinetz (1973) showed that administration of PGF2ce to 5-day pregnant hamsters caused a dramatic decrease in progesterone concentration with apparently no damage to the CL and Koering, Kirton & Thor (1973) also showed that following the administration of PGF2ct to pregnant rabbits progestin concentration decreased before any significant changes in cellular structure were observed. The present observations support those of Deane et al (1966) and Bjersing et al (1970), who showed conclusively that significant fine cytological changes in sheep CL were not evident before the 15th or 16th day of the cycle, even though involutionary changes were detectable histochemically as early as Day 12 or 13 of the cycle.…”

Section: Discussionmentioning

confidence: 94%

Effect of Prostaglandin F2 on the Ultrastructure and Function of Sheep Corpora Lutea

Umo¹

1975

Reproduction

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Early morphological changes in the ultrastructure of CL of ewes treated with prostaglandin F2alpha were examined in relation to luteal function as judged by plasma progesterone concentration. The luteolytic effect of prostaglandin F2alpha was confirmed, but there was little synchrony between morphological and functional luteolysis. Significant changes included a decrease in the amount of smooth endoplasmic reticulum, a change in the shape of mitochondria and a decrease in the number of membrane-bound granules. There was also an accumulation of lipids.

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On the mechanism of prostaglandin F2α-induced abortion in hamsters

Cited by 12 publications

References 25 publications

Patterns of Relaxin and Steroids in the Reproductive Cycle of the Common Marmoset (Callithrix Jacchus): Effects of Prostaglandin F2α on Relaxin and Progesterone Secretion during Pregnancy

Patterns of Relaxin and Steroids in the Reproductive Cycle of the Common Marmoset (Callithrix Jacchus): Effects of Prostaglandin F2α on Relaxin and Progesterone Secretion during Pregnancy

Blood Levels of Progesterone and 15-Keto-13,14-Dihydro-Prostaglandin F2 During the Normal Oestrous Cycle and Early Pregnancy in Heifers

Effect of Prostaglandin F2 on the Ultrastructure and Function of Sheep Corpora Lutea

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