On the mechanism of payload release from liposomes bound to temperature-sensitive microgel particles

Ivashkov, Oleg V.; Yakimova, Tamara; Evtushenko, Evgeniy G.; Gelissen, Arjan P. H.; Plamper, Felix A.; Richtering, Walter; Yaroslavov, Alexander A.

doi:10.1016/j.colsurfa.2019.02.069

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…Recently, Ivashkov and coworkers [267] investigated the kinetics of a thermo-induced release of doxorubicin (DOX) encapsulated in anionic liposomes (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (PS)/phosphatidylcholine (PC)) complexed with a thermosensitive N-isopropyl-acrylamide based cationic microgel. Here, the researchers synthesized microgels covered with liposomes with a liposome-to-microgel ratio range from 0.5 (unsaturated) to 30 (saturated).…”

Section: Modulation Of Drug Release Through Liposomehydrogelsmentioning

confidence: 99%

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Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

Veloso

Andrade

Castanheira

2021

Advances in Colloid and Interface Science

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Magnetic gels have been gaining great attention in nanomedicine, as they combine features of hydrogels and magnetic nanoparticles into a single system. The incorporation of liposomes in magnetic gels further leads to a more robust multifunctional system enabling more functions and spatiotemporal control required for biomedical applications, which includes on-demand drug release. In this review, magnetic gels components are initially introduced, as well as an overview of advancements on the development, tuneability, manipulation and application of these materials. After a discussion of the advantages of combining hydrogels with liposomes, the properties, fabrication strategies and applications of magnetic liposome-hydrogel composites (magnetic lipogels or magnetolipogels) are reviewed. Overall, the progress of magnetic gels towards smart multifunctional materials are emphasized, considering the contributions for future developments.

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Section: Modulation Of Drug Release Through Liposomehydrogelsmentioning

confidence: 99%

“…(B) Schematic representation of thermo-induced release of DOX from the lipogel via liposome-microgel interaction (a) or liposomeliposome interaction (b). Reprinted from [267] with permission from Elsevier, 2020.…”

Section: Modulation Of Drug Release Through Liposomehydrogelsmentioning

confidence: 99%

Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

Veloso

Andrade

Castanheira

2021

Advances in Colloid and Interface Science

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“…An alternative approach takes advantage of a synergetic combination of liposomal technologies and the versatility of hydrogels to obtain delivery systems- liposomal hydrogel systems, with improved stability which are able to offer an enhanced controlled drug release [ 30 ]. Liposomal hydrogels have been developed either by the immobilization of gels in the liposome core [ 31 , 32 , 33 , 34 ] or by the encapsulation of liposomes into the hydrogel network [ 35 , 36 , 37 , 38 ]. These systems provide a double advantage; on the one hand, hydrogels confer higher liposome stability and protection against pH and ionic strength [ 30 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics

et al. 2023

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This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin hydrogel membranes containing dispersed iron oxide nanoparticles (MNPs), i.e., magnetic-responsive gelatin. The FA release mechanisms and kinetics from magnetic-responsive liposomal gelatin were studied and compared with those obtained with conventional drug delivery systems, e.g., free liposomal suspensions and hydrogel matrices, to access the effect of liposome entrapment and magnetic field on FA delivery. FA release from liposomal gelatin membranes was well described by the Korsmeyer–Peppas model, indicating that FA release occurred under a controlled diffusional regime, with or without magnetic stimulation. DPPC:FA liposomal gelatin systems provided smoother controlled FA release, relative to that obtained with the liposome suspensions and with the hydrogel platforms, suggesting the promising application of liposomal hydrogel systems in longer-term therapeutics. The magnetic field, with low intensity (0.08 T), was found to stimulate the FA release from magnetic-responsive liposomal gelatin systems, increasing the release rates while shifting the FA release to a quasi-Fickian mechanism. The magnetic-responsive liposomal hydrogels developed in this work offer the possibility to magnetically activate drug release from these liposomal platforms based on a non-thermal related delivery strategy, paving the way for the development of novel and more efficient applications of MLVs and liposomal delivery systems in biomedicine.

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“…A combination of photocatalysts with hydrogels and hydrogel particles can provide advances in properties such as recyclability and handling. , Of major interest in that regard are gel particles consisting of three-dimensional macromolecular networks that feature high tunability and softness as well as inherent steric stabilization. , Gel particles are used as smart colloidal materials for responding to external stimuli in a fluid environment, e.g., via temperature, light, or pH . Due to the tunability of parameters such as particle size and other properties, these materials have been exploited in a wide range of applications, e.g., drug delivery or photonic crystals, and even large-scale applications in industry, such as surface coating, printing, and pharmaceutics .…”

Section: Introductionmentioning

confidence: 99%

Photoactive Graphitic Carbon Nitride-Based Gel Beads As Recyclable Photocatalysts

Cao

Barrio

Antonietti

et al. 2020

ACS Appl. Polym. Mater.

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Photocatalysis for clean hydrogen production and wastewater remediation holds great promise for society. However, despite the significant progress in this field, the recyclability of the photocatalytic materials together with good photoactivity remain a great challenge. In here, photocatalytic materials for wastewater cleaning and hydrogen production are based on the utilization of photoactive macrogel beads as the photocatalyst. To do so, we design graphitic carbon nitride-based macrogels with tailored size, swelling behavior, and photocatalytic properties. Detailed studies reveal that the catalytic activity is correlated with the polymer particle size, g-C3N4 content, and swelling behavior, enabling the optimization of the photocatalytic processes. We believe that the presented strategy together with the good photocatalytic activity and excellent recyclability constitute an opening of the path for substantial progress in this field.

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On the mechanism of payload release from liposomes bound to temperature-sensitive microgel particles

Cited by 10 publications

References 24 publications

Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics

Photoactive Graphitic Carbon Nitride-Based Gel Beads As Recyclable Photocatalysts

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