On the mechanism of hyposmia following laryngectomy in man

Henkin, R.I.; Larson, Alvin L.

doi:10.1288/00005537-197205000-00010

Cited by 33 publications

(27 citation statements)

References 8 publications

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“…[5] Published incidences of olfactory dysfunction post-TL range anywhere from 30% to 100%. [1,3,[6][7][8][9][10][11][12][13][14] A number of methodological differences explain the wide range in incidence rates between studies [ Table 1]. One influencing factor is the time post-surgery when patients are assessed.…”

Section: Olfaction Post-laryngectomymentioning

confidence: 99%

“…[1] Another key factor is the assessment mode. [1,3,[6][7][8][9][10][11][12][13][14][15] The lowest reported incidence was found in a study which assisted passage of vaporized substances up into the nasal cavity, [6] a methodology which essentially replicated the effect of nasal inhalation. Higher rates of impairment are typically noted in studies which use odor detection tests, without assisting nasal inhalation, which is a preferred methodology to determine true functional olfactory ability [ Table 1].…”

Section: Olfaction Post-laryngectomymentioning

confidence: 99%

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Olfaction following total laryngectomy

2012

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Total laryngectomy (TL) results in the complete disconnection of the upper and lower respiratory tract, ceasing orthonasal airflow. Hence, olfaction and olfactory acuity are negatively impacted. Prior to the late 1990s, impaired olfaction was simply accepted as a negative consequence of TL surgery. However, a growing body of research conducted within this past decade has demonstrated that rehabilitation is possible with a simple and effective behavioral technique. The current review outlines the literature supporting the negative impact of altered olfaction on quality of life, details of known best practice methods for olfactory assessment both for research and clinical use, and outlines the evidence for interventions known to improve olfactory performance in the TL population. Intervention for olfactory impairment should be part of a holistic, evidence-based rehabilitation process for patients post-laryngectomy. Optimized content for mobile and hand-held devicesHTML pages have been optimized of mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)

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Section: Olfaction Post-laryngectomymentioning

confidence: 99%

Section: Olfaction Post-laryngectomymentioning

confidence: 99%

Olfaction following total laryngectomy

2012

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“…It has previously been suggested that complex neural pathways critical to olfaction are interrupted by surgical denervation of the larynx. 16 Miani et al 17 proposed that degeneration of the olfactory epithelium is due to atrophy, inflammation, or disuse. These investigators noted more severe degeneration of the olfactory epithelium in biopsy samples taken from subjects who underwent laryngectomy compared with controls.…”

Section: Commentmentioning

confidence: 99%

Retronasal and Orthonasal Olfactory Ability After Laryngectomy

Leon

Catalanotto²,

Werning³

2007

Arch Otolaryngol Head Neck Surg

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“…Although the degree of such vagal-gustatory-olfactory interactions in humans is not clear, it has been suggested that an interruption of a laryngeal/vagal feedback mechanism (Henkin and Larson, 1972;Hoye et al, 1970) may contribute to olfactory dysfunction after laryngectomy (Henkin et al, 1968;Ritter, 1964). Although the hypothesis seems attractive, it is based on observations in only four cases (Henkin and Larson, 1972).…”

mentioning

confidence: 99%

“…Although the hypothesis seems attractive, it is based on observations in only four cases (Henkin and Larson, 1972). Further, laryngectomy-induced hyposmia has been shown to be largely due to the lack of nasal airflow (Mozell et al, 1986;Welge-Luessen et al, 2000).…”

mentioning

confidence: 99%

Chemosensory Function in Patients With Vagal Nerve Stimulators

Kirchner¹,

Landis²,

Haslbeck³

et al. 2004

Journal of Clinical Neurophysiology

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Chemosensory function is determined by the interplay of numerous sensory modalities. The present study aimed to evaluate the possible influence of electrical stimulation of the left-sided vagal nerve on gustatory and olfactory function in patients with vagal nerve stimulation (VNS). Gustation and olfaction were tested using psychophysical techniques; olfactory function was additionally evaluated using event-related potentials. A total of 11 subjects participated (six men and five women, aged 21 to 56 years). The vagal stimulator was run in "rapid cycle mode" in 10 patients, whereas one patient was treated with "normal mode" VNS. Subjects participated in two sessions, with the vagal stimulator switched on and off, respectively. The sequence of the two sessions was randomized across all participants. Using air-dilution, olfactometry event-related potentials to the specific olfactory stimulant H2S were recorded. Psychophysical tests were performed using the "Sniffin' Sticks" test kit, a test for retronasal olfactory function, and a gustatory test based on impregnated filter paper. The study yielded the following major results: (1) VNS produced a prolongation of P2 latencies of olfactory ERP, and (2) patients with therapeutic benefit from VNS in terms of seizure control had larger amplitudes during the on period than during the off period. In conclusion, using electrophysiological measures of olfactory function, the present study indicated a significant role of VNS in the processing of olfactory information.

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On the mechanism of hyposmia following laryngectomy in man

Cited by 33 publications

References 8 publications

Olfaction following total laryngectomy

Olfaction following total laryngectomy

Retronasal and Orthonasal Olfactory Ability After Laryngectomy

Chemosensory Function in Patients With Vagal Nerve Stimulators

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