On the Mechanism of Carisoprodol Analgesia

Abstract

Berger el a1.l have shown that carisoprodol does not show any detectable analgesic action when tested by the methods of Woolfe and MacDonald2 but that, with the silver-nitrate method of LaBelle and T i~l o w ,~ such action can be detected. The rat treated with silver nitrate recovers the mobility of the joint after treatment with carisoprodol orally even a t a dose level incapable of exercising a hypotonic effect. Using two methods, we have evaluated the central analgesic action and the myorelaxant effect of carisoprodol.