With the continuous advancement of curriculum reform, China's higher education is also gradually developing, which puts forward new requirements for cultivating talents. Probability theory and mathematical statistics, as indispensable components in mathematics education, play an important role in this process. This article elaborates on how to build a curriculum system suitable for students' lifelong learning and growth needs by reasonably classifying students and combining teaching content from the current international society's emphasis on the comprehensive development of science and technology, the support of national policies, and the school environment, and also analyzes and discusses how to apply theoretical knowledge to real life during classroom teaching to improve the practicality and efficiency of learning. Afterwards, this article also conducts an experimental test on the teaching innovation effect of the course. The test results show that the participation of these six students in introductory studies and mathematical statistics is relatively high, with the lowest being 0.8 and the highest being 0.98. This shows that student participation is relatively high after the course teaching is optimized.