On the lattice Boltzmann method simulation of a two-phase flow bioreactor for artificially grown cartilage cells

Hussein, Mostafa; Esterl, S.; Pörtner, Ralf; Wiegandt, Katharina; Becker, Thomas

doi:10.1016/j.jbiomech.2008.09.034

Cited by 18 publications

(11 citation statements)

References 10 publications

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“…Kallemeyn et al разработали пороэласти-ческую конечно-элементарную модель трехосного компрессионного биореактора, имитирующего фи-зиологическую нагрузку на суставной хрящ [131]. Hussein et al создали модель перфузионного био-реактора с использованием метода решеток Больц-ма на [132]. Культивирование клеток в проточной системе смоделировали Raimondi et al [133], а во вращающейся -Nikolaev et al [134].…”

Section: заключениеunclassified

Tissue Engineering and Regenerative Medicine Technologies in the Treatment of Articular Cartilage Defects

Басок

Севастьянов

2017

RJTAO

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1 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация 2 АНО «Институт медико-биологических исследований и технологий», Москва, Российская Федерация Важнейшими проблемами здравоохранения в индустриальном обществе являются повреждение и деге-нерация суставного хряща, что связано с ограниченными возможностями ткани к регенерации. В обзоре подробно описаны существующие и разрабатываемые технологии восстановления и замещения повреж-денных хрящевых тканей суставов. Дан анализ полученных результатов по двум основным направлени-ям: стимулирование регенерации поврежденной хрящевой ткани и выращивание элементов хрящевой ткани в биореакторах.Ключевые слова: суставной хрящ, клеточно-и тканеинженерные конструкции, регенеративная медицина, биореакторы. TISSUE ENGINEERING AND REGENERATIVE MEDICINE TECHNOLOGIES IN THE TREATMENT OF ARTICULAR CARTILAGE DEFECTS

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Section: заключениеunclassified

Tissue Engineering and Regenerative Medicine Technologies in the Treatment of Articular Cartilage Defects

Басок

Севастьянов

2017

RJTAO

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“…Additionally, the isothermal surfaces of both are surfaced in Figure 11, where the LBM isotherms are on the left and the exact are on the right. The mass transport validation has been extensively published in previous work of the authors Hussein, [7][8][9] where both diffusive and convective transports models have been deeply investigated.…”

Section: Thermal Solver Validationmentioning

confidence: 99%

An Innovative Micro-Modelling of Simultaneous Heat and Moisture Transfer during Bread Baking Using the Lattice Boltzmann Method

Hussein

Becker

2010

Food Biophysics

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A considerable fraction of the energy consumed in bread manufacturing is used for the baking process. A thorough understanding of internal moisture transfer mechanisms are important to optimise both the quality of the product and the economics of the process. From a transport phenomena point of view, bread baking has been considered as a simultaneous heat and mass transfer problem in a porous medium. Nevertheless, most efforts previously made have avoided modelling the phenomenon occurring in the microscale, although the mechanism occurs primarily in the microscale. In this work heat and moisture transfer models were developed to accomplish the mechanisms included, both in the microscale and the macroscale by means of Boltzmann's equation. Modelling and predictions of moisture transfer, heat transfer, modelling of effective moisture diffusivity, thermal conductivity and diffusivity have been investigated in this work. The microstructure in the dough samples was obtained using micro-computer tomography images from the samples prior to baking. The models were quantified and validated with measurements from the literature in order to assess the predictive models. The simulated crust development has shown a crust thickness of 0.8 cm, which is slightly higher than similar experimental results in which a dehydrated thickness of 0.5-0.6 cm was reported. The crust over-estimation in this work fits to the overheating occurring in the model. Additionally, investigations were made on the influence of different porosities (11-16%) of the bread; the boundary layer temperature at a porosity of 11% was reached after 25 min and after 17.5 min at a porosity of 16%. Therewith, the results showed that, with increasing porosity, the heat transfer rate towards the centre was higher, which matches the knowledge of experienced bakers.

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“…Also, the work performed by Hussein et al (2008b) numerically modeled the loads over cartilage cells inside one of the cartilage bioreactor. The average results for the shear and the pressure load over the grown cells are reported in Table 7.…”

Section: Simulation Of Cartilage Cells Bioreactormentioning

confidence: 99%

“…The design of this reactor offers a shear stress which is five orders of magnitude lower than the actual load inside human knees but it is five orders of magnitude higher than the bioreactor design modeled by Hussein et al (2008b). For the pressure loads, the reactor exerts fluid pressure over the cultivated cells of about 1/6 of the actual value inside the human knee.…”

Section: Simulation Of Cartilage Cells Bioreactormentioning

confidence: 99%

An innovative lattice Boltzmann model for simulating Michaelis–Menten-based diffusion–advection kinetics and its application within a cartilage cell bioreactor

Sayed

Hussein

Becker

2009

Biomech Model Mechanobiol

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Lattice Boltzmann models (LBM) are rapidly showing their ability to simulate a lot of fluid dynamics problems that previously required very complex approaches. This study presents a LBM for simulating diffusion-advection transport of substrate in a 2-D laminar flow. The model considers the substrate influx into a set of active cells placed inside the flow field. A new innovative method was used to simulate the cells activity using the LBM by means of Michaelis-Menten kinetics. The model is validated with some numerical benchmark problems and proved highly accurate results. After validation the model was used to simulate the transport of oxygen substrates that diffuse in water to feed a set of active cartilage cells inside a new designed bioreactor.

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On the lattice Boltzmann method simulation of a two-phase flow bioreactor for artificially grown cartilage cells

Cited by 18 publications

References 10 publications

Tissue Engineering and Regenerative Medicine Technologies in the Treatment of Articular Cartilage Defects

Tissue Engineering and Regenerative Medicine Technologies in the Treatment of Articular Cartilage Defects

An Innovative Micro-Modelling of Simultaneous Heat and Moisture Transfer during Bread Baking Using the Lattice Boltzmann Method

An innovative lattice Boltzmann model for simulating Michaelis–Menten-based diffusion–advection kinetics and its application within a cartilage cell bioreactor

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