On the Kinetics of the Elimination of Intravenous Fat Emulsion from the Blood Stream in Dog and Man

Hallberg, D

doi:10.1159/000175075

Cited by 3 publications

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“…Intralipid ® and chylomicrons have similar enzyme kinetic behavior when incubated in vitro [9], and the kinetics for elimination of Intralipid ® from blood are identical to those of chylomicrons [3]. These findings together with studies demonstrating that the K2 value of earlier intravenous fat tolerance test is well correlated with the fractional removal rates of triglyceride or apolipoprotein B of very low density lipoprotein [4,5], indicate that Intralipid ® can be used as a model emulsion in the study of triglyceride metabolism.…”

Section: Discussionmentioning

confidence: 90%

“…Hallberg stated that, when fat emulsion (Intralipid ®) is administered intravenously to a man or dog, zero-order kinetics are present in which fat emulsion disappears linearly from the blood at more than a certain concentration (critical concentration) [3]. The same author defined the slope as the maximal removal rate, expressed as Kl (mmol/liter of plasma/min).…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, Lewis et al had developed intravenous fat tolerance test [2]. Their method uses fat emulsion Intralipid® (Vitrum AB, Stockholm), which is similar to chylomicrons in chemical composition and in mode of catabolism in the early stage in the blood after intravenous administration, as a tracer [3]. From the fractional removal rate of fat emulsion obtained in this test, the metabolism of triglyceride rich lipoprotein (chylomicrons, very low density lipoprotein) can be indirectly determined [4,5].…”

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A Simplified Intravenous Fat Emulsion Tolerance Test

Sakuma

Hasegawa

Ikeuchi

et al. 1987

J. Clin. Biochem. Nutr.

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We developed a simplified intravenous fat emulsion tolerance test (FETT) by administering 0.25 ml/kg body weight of Intralipid (R) 10% fat emulsion in order to study the pathogenesis of hyperlipidemia. The fractional removal rate (K2) of fat emulsion was determined by nephelometry. FETT was performed on male and female normolipidemic subjects and on patients who had primary and secondary hyperlipidemia (except types I and V of W.I.O. classification). The K2 value of normolipidemic subjects ranged from 4.0 to 27.6 % /min, with a mean value of 11.5 ±4.7 (SD) %/min, (n=77). The K2 value of hyperlipidemic patients ranged from 1.8 to 18.6 % /min, and the mean value was 8.2 ± 3.3 (SD) % /min, (n =150). Compared with the data in the literature, the values and range of K2 by this simplified FETT were higher and greater, respectively, than those obtained by the earlier method of administering a higher loading dose such as 1 ml/kg body weight of Intralipid (R)® 10% fat emulsion. Good reliability and high reproducibility of K2 by the present FETT were also demonstrated. We suggest that the simplified FETT is a good tool for the study of hyperlipidemia and lipid metabolism.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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