On the kinetics of lead in the human body

Batschelet, Edward; Brand, Lukas; Steiner, Aline R

doi:10.1007/bf00280582

Cited by 33 publications

(9 citation statements)

References 11 publications

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“…However, as expected due to the smaller exchange rate for lead amounts below 50 mg, the majority of the lead is still located in the cortical bone. These numerical results are consistent with the claim that at least 90% of lead settles in the bone, see [2,3].…”

Section: Comparison Of Linear Model With Nonlinear Modelsupporting

confidence: 89%

Propagation of lead in the human body

Morrissey¹

2017

SIURO

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Abstract. Lead is a toxin that has well known side effects including fatigue, muscle pain, impaired kidney function, lower IQs for children, and brittle bones. Lead can be absorbed into the body through paint, air, water, and various other consumer products. Once ingested, blood transports lead throughout the body. The vast majority of lead absorbed in the body accumulates in the bone. Here we explore a three-compartment nonlinear ODE model for lead in blood, cortical bone, and trabecular bone. Thereafter, we compare the ODE results with a PDE model in which it is assumed that lead slowly diffuses through the bone. Numerical solutions of the model ODE equations suggest that in order to have results which are consistent with experimental data, one should assume nonlinear interactions between the blood and cortical bone, but linear interactions between the blood and trabecular bone. On the other hand, we find that the PDE model we use does not provide for a good comparison with the data. We briefly touch upon some possible reasons for this discrepancy, and ways in which the model could be improved.

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Section: Comparison Of Linear Model With Nonlinear Modelsupporting

confidence: 89%

Propagation of lead in the human body

Morrissey¹

2017

SIURO

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“…Different authors have proposed one (23,68), two (I , 7, 63, 64), three (4,33,43,53,66), four (13,23,44,45,60), and even five (6) compartments in human metabolic models. The simplest model that gave a good fit in the present study was the twocompartment one.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16] years, that of Y (3) was 0.3 (range 0.0-2.6) p.mol/I, and that of T V2 (3) was > 100 (range 4.9-00) years.…”

Section: Mathematical Analysismentioning

confidence: 99%

Kinetics of lead in blood after the end of occupational exposure.

Schütz¹,

Skerfving²,

Ranstam³

et al. 1987

Scand J Work Environ Health

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“…Orally administered lead is poorly bioavailable, with gastrointestinal absorption ranging from 2 to 40% of the dose in rats [9]. Although bile [19] and phospho lipids [20] appear to enhance lead absorption, the bioavailability in rats of phospholipidbound lead from the diet was the same as that of lead acetate [21], In humans only about 16% of the total lead elimination is via bile, saliva, and intestinal secretions [22], Since the extent of enterohepatic cycling appears to be small in rats and should be even less in humans, interruption of enterohepatic cy cling does not appear to afford a useful means for significantly increasing total body lead elimination.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Nonabsorbable Chelating Resin on Lead Absorption, Elimination, and Accumulation in the Rat

Aungst¹,

Lora²,

Losi³

et al. 1982

Pharmacology

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In rats, oral administration of lead-chelating resin (Chelex-100®) reduced the absorption of an oral lead dose (10 mg/kg) when both doses were given at approximately the same time. The same oral resin did not reduce blood lead concentrations when administered after the lead dose had been absorbed or after systemic lead administration (1 mg/kg, intra-cardiac), indicating that the resin did not influence lead elimination. As a dietary supplement the resin was also ineffective in reducing blood and kidney lead concentrations in rats exposed to lead in drinking water. Thus, the possible therapeutic uses of this lead-chelating resin may be limited.

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On the kinetics of lead in the human body

Abstract: A compartment model is derived for the kinetics of lead in the human body. The parameters are estimated from field data. Numerical solutions of the equations are obtained. They are used to discuss recent theories on lead intake, in particular from the atmosphere.

Cited by 33 publications

References 11 publications

Propagation of lead in the human body

Propagation of lead in the human body

Kinetics of lead in blood after the end of occupational exposure.

Effects of a Nonabsorbable Chelating Resin on Lead Absorption, Elimination, and Accumulation in the Rat

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