On the issue of substantiating a high degree of one-time marginal probability of detecting pentasodium salt of diethylenetriaminepentaacetic acid in the working area

Abstract

Introduction. Pentasodium salt of diethylenetriaminepentaacetic acid, which is widely used in the chemical industry as an initiator of polymerization processes, has a wide range of toxic properties. However, the normative hygienic standard for the working area in the whole wide world has not yet been established. Purpose of the study. Experimental substantiation of a large number of one-time MPC of pentasodium salt of diethylenetriaminepentaacetic acid in the environment. Materials and methods. Pentasodium salt of diethylenetriaminepentaacetic acid, CAS No. 140-01-2, outbred male rats weighing 200-240 g. Research in the field of the protection of animals used for scientific purposes (ETS N 123) is aimed at studying the protection of animals used for scientific purposes. Examinations of experimental studies on animals using generally accepted and unified methods. Statistical processing of research materials was carried out using standard application programs Statistica 10.0. Results. The mean lethal dose of diethylenetriaminepentaacetic acid pentasodium salt (DL50) for male white rats is 1702.8±228mg/kg, the acute inhalation action threshold (Limac) is the concentration of 4.62±0.4mg/m3, the irritant action threshold (Limir) - concentration 2.5±0.2 mg/m3, irritating zone (Zir) equals 2.9. Conclusion. A high one-time maximum allowable concentration of the pentasodium salt of diethylenetriaminepentaacetic acid in the environment, equal to 0.7 mg/m3, has been scientifically substantiated and experimentally found. Hazard class 2, limiting indicator of harmfulness - irritant effect. Restrictions. The authors transfer the editors of the exclusive right to natural disasters (publications), other use of the materials of the articles without citing the authors for a specific publication is strictly prohibited. Ethics. The material of the article was approved by the ethics committee at the Federal Budgetary Institution "Novosibirsk Research Institute of Hygiene" of Rospotrebnadzor (No. 2 of January 14, 2022).