Surfaces in 4D Riemannian space forms have been investigated extensively. In contrast, only few results are known for surfaces in 4D neutral indefinite space forms R 4 2 (c). Thus, in this paper we study space-like surfaces in R 4 2 (c) satisfying certain simple geometric properties. In particular, we classify space-like surfaces in E 4 2 with constant mean and Gauss curvatures and null normal curvature. We also classify Wintgen ideal surfaces in R 4 2 (c) whose Gauss and normal curvatures satisfy K D = 2K.