On the intermediates in zeolite Y synthesis

Fahlke, Β.; Starke, Peter; Seefeld, V.; Wieker, W.; Wendlandt, K.‐P.

doi:10.1016/0144-2449(87)90052-2

Cited by 39 publications

(7 citation statements)

References 11 publications

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“…Unfortunately, the average diameter of these particles was too big for our purpose (~240 nm). As known, an aging step prior to crystallization strongly affects crystal size by an increase in a number of nuclei [ 45 , 57 , 58 ]. It has been reported that a decrease in aging temperature and time results in substantially smaller NaA zeolite particles [ 59 , 60 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

et al. 2020

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Prostate cancer is the second most frequent malignancy in men worldwide. Unfortunately, current therapies often lead to the onset of metastatic castration-resistant prostate cancer (mCRPC), causing significant mortality. Therefore, there is an urgent need for new and targeted therapies that are advantageous over the current ones. Recently, the PSMA-targeted radioligand therapy of mCRPC has shown very promising results. In line with this, we described the synthesis of a new radioimmunoconjugate, 223RaA-silane-PEG-D2B, for targeted mCRPC therapy. The new compound consists of a NaA zeolite nanocarrier loaded with the α-particle emitting Ra-223 radionuclide, functionalized with the anti-PSMA D2B antibody. Physicochemical properties of the synthesized compound were characterized by standard methods (HR-SEM, TEM, XRD, FTIR, EDS, NTA, DLS, BET, TGA). The targeting selectivity, the extent of internalization, and cytotoxicity were determined in LNCaP C4-2 (PSMA+) and DU-145 (PSMA-) cells. Our results supported the 223RaA-silane-PEG-D2B synthesis and revealed that the final product had a diameter ca. 120 nm and specific activity 0.65 MBq/1mg. The product was characterized by a high yield of stability (>95% up to 12 days). The conjugation reaction resulted in approximately 50 antibodies/nanoparticle. The obtained radioimmunoconjugate bound specifically and internalized into PSMA-expressing LNCaP C4-2 cells, but not into PSMA-negative DU-145 cells. 223RaA-silane-PEG-D2B demonstrated also potent cytotoxicity in LNCaP C4-2 cells. These promising results require further in vivo evaluation of 223RaA-silane-PEG-D2B with regard to its toxicity and therapeutic efficacy.

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Section: Resultsmentioning

confidence: 99%

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

et al. 2020

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“…The synthesis gel molar composition is a critical factor in zeolites synthesis methodologies. It was found that a high Na 2 O content in the reaction mixture induces a crystalline size decrease because of nucleation increase [8,16] On the other hand, the aging step prior to crystallization strongly affects the crystal size by the increase in the number nuclei that promotes the pure phase FAU formation [9,33]. An increase in aging temperature (˃30 °C) and time (˃24 h) results in substantially larger zeolite particle sizes [13,14,18].…”

Section: Resultsmentioning

confidence: 99%

Green synthesis of nanocrystalline faujasite zeolite

Reinoso

Adrover

Pedernera

2018

Ultrasonics Sonochemistry

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In this work, the synthesis of 28 and 38 nm Na-Y zeolite nanocrystals is reported. The process was performed via green synthesis without any organic structure directing agents (SDAs), at low temperature and applying ultrasound-assisted aging. The zeolite nanoparticles obtained were characterized by X ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and N adsorption - desorption isotherm at 77 K. A simple, fast, efficient and environmentally friendly procedure to synthetize nanocrystalline FAU zeolite is described in the present study. The sonochemical pretreatment was found to directly affect the Na-Y zeolite properties. The final product obtained via ultrasound pretreatment shows high phase purity and crystallinity degree with crystal size smaller than 38 nm and elevated surface area (S ∼ 950 m g). The hierarchical micro- and mesoporous FAU zeolites exhibit a pore volume of ∼0.4 cm g.

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“…The molydate method [24][25][26][27] was used for the characterization of the condensation of silicate species in the aluminosilicate solid. The yellowish silico-molybdic acid complex was due to the reaction of silicate monomers and molybdic acid.…”

Section: Methodsmentioning

confidence: 99%

“…For this reason, we investigated the alkali activation of metakaolin as a very pure aluminosilicate source of Si/Al 5 1 which could be observed as a model system for the processes that are involved during aging and hardening (''geopolymerization''). Using the combination of mechanical testing and infrared absorption spectroscopy together with investigations by the molybdate measurement-a method known to be sensitive to the characterization and quantification of monomer, dimer, and oligomer silicate units [24][25][26][27] -a distinction between the silicate species responsible for the main variation in strength during aging could be achieved. Some preliminary results were recently presented in Conference contributions.…”

Section: Introductionmentioning

confidence: 99%

Weakening of Alkali‐Activated Metakaolin During Aging Investigated by the Molybdate Method and Infrared Absorption Spectroscopy

Rüscher

Mielcarek

Lutz³

et al. 2010

Journal of the American Ceramic Society

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Aluminosilicate gels were synthesized by mixing metakaolin with potassium water glass solution. Mechanical strength values showed a strong increase between 25 and 100 h but decreased again above 200 h for aging at 25°C. A similar curve was observed during aging at 50°C but the maximum strength shifted to shorter time. Aging at 90° and 130°C revealed only the decreasing wing in mechanical strength. The strengthening and weakening during aging at 25°C were further investigated by the molybdate method and infrared absorption spectroscopy. The results indicate basically that different time‐dependent formations of two structural units dominate the mechanical properties: (i) A fast formation of longer (polymeric) silicate chains is enforced by the consumption of hydroxide in the solution of metakaolin up to about 25 h of aging. (ii) An aluminosilicate network grows slowly and encloses the chain‐like units giving rise to an initial increase in strength within 100 h. During further aging the destruction of the polysilicate chains weakens the geopolymer. The destruction of the chain‐like units is explained by the increasing amount of hydroxide produced during network condensation. The results imply that the same reactions occur for aging at a higher temperature but on faster time scales.

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On the intermediates in zeolite Y synthesis

Cited by 39 publications

References 11 publications

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I

Green synthesis of nanocrystalline faujasite zeolite

Weakening of Alkali‐Activated Metakaolin During Aging Investigated by the Molybdate Method and Infrared Absorption Spectroscopy

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