In this paper, we derive regular criteria via pressure or gradient of the velocity in Lorentz spaces to the 3D Navier-Stokes equations. It is shown that a Leray-Hopf weak solution is regular on (0, T ] provided that either the norm Π L p,∞ (0,T ;L q,∞ (R 3 )) with 2/p + 3/q = 2 (3/2 < q < ∞) or ∇Π L p,∞ (0,T ;L q,∞ (R 3 )) with 2/p + 3/q = 3 (1 < q < ∞) is small. This gives an affirmative answer to a question proposed by Suzuki in [26, Remark 2.4, p.3850]. Moreover, regular conditions in terms of ∇u obtained here generalize known ones to allow the time direction to belong to Lorentz spaces. MSC(2000): 76D03, 76D05, 35B33, 35Q35