The energy of pair interactions between metal nanoparticles of different sizes is shown to be able to increase upon coagulation due to the additional electrostatic effect resulting from mutual heteropolar charging of the particles. The tunnel electron transfer occurring upon the collisions between particles of dif ferent sizes may be the reason for the charging. The transfer is caused by the dependence of the electron work function on the particle size. The electron transfer through the interparticle gap equalizes the Fermi levels in particles of different sizes and is associated with this dependence. Using the example of bimodal silver nano colloids, it is shown that mutual heteropolar charging of particles with different sizes may accelerate the coag ulation of polydisperse colloidal systems by an order of magnitude or more as compared with monodisperse systems, in which this effect is absent.