On the interaction of cu2+ with the heavy dipeptide gly—trp

Nascimento, Otaciro Rangel; Tabak, Marcel

doi:10.1016/0162-0134(84)85002-3

Cited by 11 publications

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“…An interesting model system, where H-bonds and cation−π interactions connect Cu ions, is the compound aqua(glycyl- L -tryptophanato)copper(II) dihydrate [Cu II Gly-Trp]. The structure of this compound was reported by Hursthouse et al The electronic structure of the copper ions was characterized by light absorption and EPR studies of aqueous solutions at different pH values and in single-crystal samples of Cu II Gly-Trp . No information was obtained in that work about the magnitudes of the interactions between Cu(II) ions, which is then the main purpose of this paper.…”

Section: Introductionmentioning

confidence: 99%

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: Cu^IIGly-Trp

2004

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The structure of the copper compound with the peptide Gly-Trp belongs to the space group P212121, with Z = 4. The four chemically identical but magnetically nonequivalent Cu(II) molecules in the unit cell are weakly connected by a network of biologically relevant pathways involving hydrogen bonds and cation−π interactions. The magnitudes of the exchange interactions between copper ions (J) transmitted along these paths were evaluated from the angular variation of the line width and the collapse of the EPR lines observed at 9.5 and 35 GHz with the magnetic field in the three crystalline planes of oriented single-crystal samples. Values |J|/k B = 3 ± 1 and 12 ± 3 mK were obtained for the couplings transmitted through bridges containing H-bonds, and |J|/k B = 5 ± 2 mK for the interaction transmitted through bridges containing a cation−π contact. These magnitudes are analyzed in terms of the structural information about the intervening long chemical paths.

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Section: Introductionmentioning

confidence: 99%

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: Cu^IIGly-Trp

2004

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“…11 A number of studies have found tyrosine to be useful during conditions of stress, cold, and fatigue. 12 It has also been found that manic patients do better in tyrosine depleted diet. So it is quite necessary to suppress tyrosine in blood plasma of patients suffering from mania.…”

Section: Introductionmentioning

confidence: 99%

Aromatic amino acids in high selectivity bismuth(iii) recognition

Ghatak

Dey²,

Sen

et al. 2013

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The three aromatic amino acids, tyrosine, tryptophan and phenylalanine, play different physiological roles in life processes. Metal ions capable of binding these amino acids may aid in the reduction of effective concentration of these amino acids in any physiological system. Here we have studied the efficacy of some heavy metals for their complexation with these three amino acids. Bismuth has been found to bind selectively with these aromatic amino acids and this was confirmed using spectrofluorimetric, spectrophotometric and cyclic voltammetric studies. The series of heavy metals has been chosen because each of these metals remains associated with the others at very low concentration levels and Bi(III) is the least toxic amongst the other elements. So, selective recognition for Bi(III) would also mean no response for the other heavy elements if contaminants are present even at low concentration levels. The affinity towards these amino acids has been found to be in the order tryptophan < phenylalanine < tyrosine. The association constants of these amino acids have been calculated using Benesi-Hildebrand equations and the corresponding free energy change has also been calculated. The values of the association constants obtained from BH equations using absorbance values corroborate with the Stern-Volmer constants obtained from fluorimetric studies. The evidence for complexation is also supported by the results of cyclic voltammetry.

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“…Essa estrutura deve corresponder a coordenacao de dois nitrogenios em posicoes nao equivalentes (urnnitrogenio peptidico e 0 outro amina), e por isso escondidos pela largura da linha de campo alto. Sabendo-se tambem que a distancia media Cu-N de nitrogenios peptidicos estA em torno de 1,92 A, enquanto que para nitrogenios do amina terminal e de 2,00 A (Nascimento, 1985). A fig.…”

Section: Espectros De Emissio Da Fluorescenciaunclassified

Estudos espectroscópicos de complexos de glicil-tirosina e tirosil-glicina com o íon Cu(II)

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On the interaction of cu2+ with the heavy dipeptide gly—trp

Cited by 11 publications

References 10 publications

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: Cu^IIGly-Trp

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: Cu^IIGly-Trp

Aromatic amino acids in high selectivity bismuth(iii) recognition

Estudos espectroscópicos de complexos de glicil-tirosina e tirosil-glicina com o íon Cu(II)

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On the interaction of cu2+ with the heavy dipeptide gly—trp

Cited by 11 publications

References 10 publications

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: CuIIGly-Trp

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: CuIIGly-Trp

Aromatic amino acids in high selectivity bismuth(iii) recognition

Estudos espectroscópicos de complexos de glicil-tirosina e tirosil-glicina com o íon Cu(II)

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Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: Cu^IIGly-Trp

Electron Paramagnetic Resonance Study of Weak Exchange Interactions between Metal Ions in a Model System: Cu^IIGly-Trp