On the incidence of blood group O and Gm(−1) phenotypes in patients with malignant melanoma

Walter, H.; Brachtel, R; Hilling, Maria

doi:10.1007/bf00277688

Cited by 10 publications

References 7 publications

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Genetic studies in multiple myeloma. II. Immunoglobulin allotype associations

Leech

Brown

Schanfield

1985

Cancer

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A weakly positive but statistically significant association between HLA‐Cw5 and myeloma has been reported in black patients. The authors attempted to determine whether immunoglobulin allotypes of the Gm series demonstrate any such association. They were identified in the sera of 29 black patients and 160 healthy black control subjects by a standard hemagglutination‐inhibition technique. The results indicate that the G3m(g5) allotype is significantly associated with myeloma. Furthermore, addition of that immunoglobulin allotype to a Gm phenotype that is netatively associated with myeloma gives a phenotype that is positively associated with the disease, both associations being statistically significant. It was concluded that G3m(g5) is a marker of inherited susceptibility to myeloma in black Americans. Furthermore, as G3m(g5) is present in almost 50% of normal control subjects, it was proposed that its expression in a much greater proportion of patients may be related to an underlying genetic rearrangement that is also associated with neoplastic transformation.

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Genetic studies in multiple myeloma. II. Immunoglobulin allotype associations

Leech

Brown

Schanfield

1985

Cancer

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Blood groups and malignant melanoma

Karakousis

Evlogimenos

Suh

1986

Journal of Surgical Oncology

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The charts of 168 patients with malignant melanoma were reviewed with regard to the incidence of the major blood groups. Blood group A was encountered in 39.9%, Group B in 7.7%, Group AB in 3%, and Group O in 49.4%. Although blood group O had a higher frequency compared to that of the general white population of various series, the difference was not significant. Patients with blood group A had a median survival of 67.7 months whereas patients with blood group O had a median survival of 46.6 months (p = 0.04). The improved survival for blood group A remained significant only in female patients, when the sexes were considered separately. However, group A had an incidence of 24% in early Clark's lesions while that incidence in group O was 9.8%. Female patients had longer median survival (86 months) than male patients (44 months).

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