On the incidence of antibiotic resistance among aerobic Gram-negative rods isolated in Greek hospitals

Legakis, Nicholas J.; Tzouvelekis, L. S.; Tsakris, Athanassios; Legakis, J.N.; Vatopoulos, A.

doi:10.1016/0195-6701(93)90052-2

Cited by 32 publications

(22 citation statements)

References 8 publications

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“…We conducted a retrospective medical chart review of all admissions to the Third Department of Medicine, Athens University, Sotiria General Hospital, Athens, Greece, that were due to AP from January 1, 1997, through December 31,2001. Criteria for diagnosis of AP were the isolation of the same pathogen from urine and blood cultures or the simultaneous presence of (1) fever, defined as an axillary temperature of 38°C or greater; (2) 14 In all cases, a positive urine culture was necessary for inclusion in the study.…”

Section: Data Collectionmentioning

confidence: 99%

Acute Pyelonephritis in Adults

Efstathiou¹,

Pefanis²,

Tsioulos³

et al. 2003

Arch Intern Med

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Background: To formulate a classification tool for early recognition of patients admitted with acute pyelonephritis (AP) who are at high risk for failure of treatment or for death.Methods: A retrospective chart review of 225 patients (102 men) admitted with AP. We considered 13 potential risk factors in a multivariate analysis.Results: Recent hospitalization, previous use of antibiotics, and immunosuppression were found to be independent correlates of the prevalence of resistant pathogens in both sexes. Additional predictors included nephrolithiasis in women and a history of recurrent AP in men. Prolonged hospitalization should be expected for a man with diabetes and long-term catheterization who is older than 65 years or for a woman of any age with the same characteristics, when the initial treatment was changed according to the results of urine culture. For mortality prediction, we derived an integer-based scoring system with 6 points for shock, 4 for bedridden status, 4 for age greater than 65 years, and 3 for previous antibiotic treatment for men and 6 points for shock, 4 for bedridden status, 4 for age greater than 65 years, and 3 for immunosuppression for women. Among patients with at least 11 points, the risk for in-hospital death was 100% for men and 91% for women. Conclusions:Simple variables available at presentation can be used for risk stratification of patients with AP. The additional identification of certain risk factors by means of a carefully obtained history could contribute to early recognition of patients infected by resistant bacteria and optimize the selection of antimicrobial agents.

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Section: Data Collectionmentioning

confidence: 99%

Acute Pyelonephritis in Adults

Efstathiou¹,

Pefanis²,

Tsioulos³

et al. 2003

Arch Intern Med

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“…Our speculation that B. fragilis would form yellow colonies, but aerobic organisms blue ones, was confirmed. The medium is most likely to be of value where aminoglycoside resistance of gram-negative aerobes is common (7,18). A combination of this medium with direct immunofluoresence (22) might provide the rapid and presumptive identification of B. fragilis.…”

Section: Discussionmentioning

confidence: 99%

“…Aminoglycosides, well known to inhibit the growth of gram-negative facultatives, have been suggested for some time as additives in selective media for the growth of anaerobes. However, these drugs are becoming less effective due to increased resistance, especially in South European countries (7,18).…”

Section: Original Articlementioning

confidence: 99%

“…Aerobes were from the collection of the Department of Microbiology form the Medical School of Athens University and consisted of the following: Escherichia coli (20), Proteus mirabilis (18), P. 6ulgatus Anaerobic bacteria were provided by four different hospitals (Evangelismos, Laiko, Agia Sofia and Aglaia Kyriakou) situated in Athens, and consisted of the following: Bacteroides fragilis (63), B. thetaiotaomicron (1), Pre6otella melaninogenica (7), Clostridium perfringes (14), Peptococcus spp (26), Peptostreptococcus spp (9).…”

Section: Microorganismsmentioning

confidence: 99%

See 1 more Smart Citation

A New Selective and Differentiative Medium for the Isolation ofBacteroides fragilis

Papastathopoulou

1998

Microbial Ecology in Health and Disease

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“…In spite of this restriction policy, a second survey during 1992 found a resistance figure of 4%. 24 If the hypothesis that cephalosporinase derepression is a pre-requisite for imipenem resistance is correct, the overprescription of some " popular" cephalosporins in Greek hospitals might share some responsibility for the maintenance and further development of resistance to imipenem.…”

Section: El and E2mentioning

confidence: 99%