Abstract. We characterize the circular periodic solutions of the generalized Lennard-Jones Hamiltonian system with two particles in R n , and we analyze what of these periodic solutions can be continued to periodic solutions of the anisotropic generalized Lennard-Jones Hamiltonian system.We also characterize the periods of antiperiodic solutions of the generalized Lennard-Jones Hamiltonian system on R 2n , and prove the existences of 0 < τ * ≤ τ * * such that this system possesses no τ /2-antiperiodic solution for all τ ∈ (0, τ * ), at least one τ /2-antiperiodic solution when τ = τ * , precisely 2 n families of τ /2-antiperiodic circular solutions when τ = τ * * , and precisely 2 n+1 families of τ /2-antiperiodic circular solutions when τ > τ * * . Each of these circular solution families is of dimension n − 1 module the S 1 -action.