On the genetics of psoriasis

Ananthakrishnan, Radha; Eckes, L; Walter, H.

doi:10.1007/bf02984078

Cited by 20 publications

(2 citation statements)

References 8 publications

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“…A genetic component has been established in psoriasis, but the mode of inheritance has been difficult to elucidate. Autosomal dominant inheritance with reduced penctrance (12,24,25), double recessive (12) and multifactorial inheritance ( 11,26) have been suggested. As the present analysis has been based on a sample of psoriatics with no apparent genetic heterogeneity, estimations of the mode of inheritance seems possible.…”

Section: Key To Abbreviations: Psoriasis (P) Present ( +) or Absent (...mentioning

confidence: 99%

“…but not incompatible with autosomal dominant inheritance with reduced penetrance or multifactorial inheritance. A multifactorial origin is most likely according to analyses published by Watson et al (11), and Ananthakrishnan et al (26). Complex segregation analysis has been applied recently to Lomholts family material and the preliminary resuhs (27) are in favour of a major locus for psoriasis with addition of a strong polygenic component.…”

Section: Key To Abbreviations: Psoriasis (P) Present ( +) or Absent (...mentioning

confidence: 99%

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Psoriasis in first-degree relatives of psoriatic twins

Brandrup

1984

Acta Derm Venereol

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Analysis of the presence of psoriasis in all first-degree relatives of psoriatic twin probands, 38 monozygotic (MZ) and 24 dizygotic (DZ), has been performed in order to clarify if genetic heterogeneity might be present (the twin-family method). The probands were derived from a population based sample of like-sexed twin pairs. An almost identical frequency of psoriasis in parents, siblings and children, with no sex difference, was found. By comparisons of empirical risk figures for psoriasis in first-degree relatives of concordant as compared with discordant MZ probands and HLA-B 13 and/or HLA-B 17 positive MZ probands compared with MZ probands lacking these antigens, no clue to the presence of genetic heterogeneity was found. An almost identical risk in co-twins and ordinary siblings of DZ-probands was found. The data were incompatible with autosomal recessive or X-linked inheritance, but not incompatible with autosomal dominant inheritance with reduced penetrance or with multifactorial inheritance.

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Section: Key To Abbreviations: Psoriasis (P) Present ( +) or Absent (...mentioning

confidence: 99%

Section: Key To Abbreviations: Psoriasis (P) Present ( +) or Absent (...mentioning

confidence: 99%