On the genetics of hypodontia and microdontia: synergism or allelism of major genes in a family with six affected members.

Lyngstadaas, Ståle Petter; Nordbø, H; Gedde‐Dahl, T.; Thrane, P. S.

doi:10.1136/jmg.33.2.137

Cited by 33 publications

(29 citation statements)

References 16 publications

(1 reference statement)

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“…A similar patient from Turkey, a child of first cousins, has also been described 25. The Norwegian sibs reported26 could also well have the autosomal recessive condition described here. A brother and sister from Lebanon with only a few permanent teeth and thin nails were recently reported27 with the suggestion that they may have the condition described by Fried 24.…”

Section: Discussionmentioning

confidence: 51%

Recessively inherited lower incisor hypodontia

Pirinen

2001

Journal of Medical Genetics

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Section: Discussionmentioning

confidence: 51%

Recessively inherited lower incisor hypodontia

Pirinen

2001

Journal of Medical Genetics

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“…Oligodontias têm sido frequentemente relatadas em humanos (Lyngstadaas et al, 1996); registros em animais domés-ticos, como ratos e cães também são comuns na literatura (Butkovic et al, 2001). Hoff e Hoff (1996) …”

Section: Agênese Múltipla (= Oligodontia)unclassified

Variações na fórmula dentária de Otaria byronia Blainville (Pinnipedia, Otariidae) no Pacífico: registro de um novo tipo de anomalia

Drehmer

Dornelles

Loch

2009

NBC

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ResumoSão apresentados 14 espécimes da população pacífi ca (Chile e Peru) do leão-marinhosul-americano [Otaria byronia (Blainville, 1820)] contendo anomalias dentárias. Agêneses de pós-caninos, especialmente do PC6 superior, são as anomalias mais frequentes relacionadas com a instabilidade natural desses dentes. Enquanto sua ocorrência é considerada um atavismo táxico, especula-se que a ocorrência deste dente em outras espécies de otarídeos possa ser considerada como uma estrutura ora vestigial, ora rudimentar. Dentes pós-caninos extranumerários mandibulares na posição do PC6 corroboram a hipótese dos atavismos espontâneos, remontando aos primórdios da evolução dos Pinnipedimorpha no Oligo/Mioceno. O primeiro caso de agênese múltipla para Otaria byronia é apresentado, onde estão ausentes, simetricamente, os PC2 e 3 superiores e os PC4 inferiores, caracterizando uma oligodontia, comum em outras espécies de mamíferos tais como os cães e os humanos. O estudo das anomalias dentárias pode fornecer um suporte apreciável de informação no que diz respeito à evolução dentária dos pinipédios em geral, e contribuir na elucidação das relações fi logenéticas entre os Carnivora Arctoidea.Palavras-chave: agênese, atavismos, extranumerários, oligodontia. AbstractFourteen South American sea lion specimens from the Pacifi c population (Chile and Peru) containing dental anomalies are presented from a total sample of 296 specimens. Postcanine agenesis, especially in the upper PC6, is the most frequent anomaly related to the natural instability of this tooth in this species. Although its occurrence is treated as a taxic atavism, we speculate that its presence in other otariid species may be regarded as a vestigial or rudimentary structure. Lower post-canine extra teeth at the PC6 position, corroborates the spontaneous atavism hypothesis back in time to the beginning of the Pinnipedimorpha evolution at Oligo/Miocene. The fi rst case of multiple agenesis for Otaria byronia is here presented. The upper PC2 and PC3 and the lower PC4 are absent on both sides characterizing an oligodonty, a dental anomaly common in other mammal species,

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“…Hypodontia is commonly reported in coexistence with other dental clinical features (2,3,6) such as taurodontism, peg-shaped incisors, teeth rotations and generalized spacing, canine-lateral incisor transposition, retained primary teeth, or abnormal dental morphologies (1). Microdontia is also highly reported in hypodontia case reports (3,24,25).…”

Section: Introductionmentioning

confidence: 99%

Hypodontia, Gender-Based Differences and its Correlation with other Dental Clinical Features in Kosovar Adolescents

Reshitaj¹,

Krasniqi²,

Reshitaj³

et al. 2019

Acta Stomatol Croat

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Hipodoncija, razlike prema spolu i povezanost s drugim dentalnim kliničkim značajkama kosovskih adolescenataUvod Hipodoncija je dentalna anomalija kod koje kongenitalno nedostaje manje od šest zuba (osim trećih molara) (1, 2). Drugi nazivi za tu pojavu su dentalna ageneza, oligodoncija te anodoncija, no u ovom radu korišteni su termini ageneza zuba ili hipodoncija zato što se odnose na razvojni nedostatak manjka zuba, a oligodoncija i anodoncija smatraju se težim oblicima ageneze zuba kada ih uglavnom nedostaje više od šest, ili uopće nema zuba (3). Smatra se da hipodoncija ima snažnu genetsku (4, 5) komponentu te je česta kod pacijenata koji imaju i druge ektodermalne anomalije te kod nesindromskih pacijenata s rascjepom usnice i/ili nepca (CLP) (6). Drugi okolišni čimbenici kao što su trauma, infekcije i toksini mogu biti uključeni u incidenciju hipodoncije (3, 7).Ovisno o istraživanoj populaciji, prevalencija hipodoncije varira od 0,03 do 10,1 %, pa je to najprevalentnija dentofacijalna anomalija kod ljudi, s time da je u posljednjih nekoliko desetljeća zabilježen porast incidencije, posebno među pripadnicima bijele rase (2, 8). U nekim istraživanjima autori ističu povećanu prevalenciju hipodoncije kod žena u odno-Abstract Aim: The primary aim of this study was to evaluate the gender-based differences in patients with hypodontia. As a secondary outcome, the study looked into the correlation between hypodontia and other dental clinical features among Kosovar adolescents. Material and Methods: 3,306 students, aged between 15-21 years were examined in schools in Kosovo. Examinations were performed using a dental mirror to assess the number of teeth present, and dental impressions were taken from hypodontia subjects. Panoramic and periapical radiographs, as well as intraoral photographs, were taken in subjects who were suspected to have hypodontia to verify the diagnosis. Results: 77 of the examined subjects had hypodontia, among which 46 were females (59.7%) and 31 were males (40.3%). The most frequently missing teeth were the maxillary lateral incisors, followed by the mandibular second premolars. 68 patients (88.3%) had at least one dental clinical feature concurrent with hypodontia. Conclusion: No significant difference was noted in the prevalence of hypodontia according to gender. Teeth rotation was the most commonly observed clinical feature followed by inclination.

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On the genetics of hypodontia and microdontia: synergism or allelism of major genes in a family with six affected members.

Cited by 33 publications

References 16 publications

Recessively inherited lower incisor hypodontia

Recessively inherited lower incisor hypodontia

Variações na fórmula dentária de Otaria byronia Blainville (Pinnipedia, Otariidae) no Pacífico: registro de um novo tipo de anomalia

Hypodontia, Gender-Based Differences and its Correlation with other Dental Clinical Features in Kosovar Adolescents

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