On the genetics contribution to molar incisor hypomineralization

Vieira, Alexandre R.

doi:10.1111/ipd.12439

Cited by 18 publications

(14 citation statements)

References 7 publications

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“…In addition to systemic aetiological factors, genes and epigenetic actions appear to also mediate environmental influences on the gene expression. This might support the view that MIH occurs as a result of certain life events, while the mechanism linking systemic and genetic factors might explain the different severities of MIH in teeth forming at the same time although in different locations (Vieira 2019;Vieira and Manton 2019).…”

Section: Comments Arising From the Evaluation Of The Existing Aetiology Literaturesupporting

confidence: 71%

“…A genetic predisposition to MIH in conjunction with one or several other aetiological factors has been proposed, as some authors identified certain variants in amelogenesis-related genes ENAM, AMELX or MMP20 (Jeremias et al 2013a , b , 2016 ; Kühnisch et al 2014 ; Hočevar et al 2020 ; Pang et al 2020 ) or immune response-related genes (Bussaneli et al 2019 ) in children with MIH. More recently, epigenetic influences of certain environmental factors have also been established (Teixeira et al 2018 ; Vieira 2019 ; Vieira and Manton 2019 ). Epigenetics describes the way in which gene–environment and gene–gene interactions cause the expression of a phenotype.…”

Section: Aetiology Of Mihmentioning

confidence: 99%

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Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Lygidakis

Garot

Somani

et al. 2021

Eur Arch Paediatr Dent

161

192

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Aim To update the existing European Academy of Paediatric Dentistry (EAPD) 2010 policy document on the ‘Best Clinical Practice guidance for clinicians dealing with children presenting with Molar-Incisor-Hypomineralisation (MIH).’ Methods Experts, assigned the EAPD, worked on two different topics: (A) Aetiological factors involved in MIH, and (B) Treatment options for the clinical management of MIH. The group prepared two detailed systematic reviews of the existing literature relevant to the topics and following a consensus process produced the updated EAPD policy document on the ‘Best Clinical Practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH).’ The GRADE system was used to assess the quality of evidence regarding aetiology and treatment which was judged as HIGH, MODERATE, LOW or VERY LOW, while the GRADE criteria were used to indicate the strength of recommendation regarding treatment options as STRONG or WEAK/CONDITIONAL. Results (A) Regarding aetiology, it is confirmed that MIH has a multifactorial aetiology with the duration, strength and timing of occurrence of the aetiological factors being responsible for the variable clinical characteristics of the defect. Perinatal hypoxia, prematurity and other hypoxia related perinatal problems, including caesarean section, appear to increase the risk of having MIH, while certain infant and childhood illnesses are also linked with MIH. In addition, genetic predisposition and the role of epigenetic influences are becoming clearer following twin studies and genome and single-nucleotide polymorphisms analyses in patients and families. Missing genetic information might be the final key to truly understand MIH aetiology. (B) Regarding treatment options, composite restorations, preformed metal crowns and laboratory indirect restorations provide high success rates for the posterior teeth in appropriate cases, while scheduled extractions provide an established alternative option in severe cases. There is great need for further clinical and laboratory studies evaluating new materials and non-invasive/micro-invasive techniques for anterior teeth, especially when aesthetic and oral health related quality of life (OHRQoL) issues are concerned. Conclusions MIH has been studied more extensively in the last decade. Its aetiology follows the multifactorial model, involving systemic medical and genetic factors. Further focused laboratory research and prospective clinical studies are needed to elucidate any additional factors and refine the model. Successful preventive and treatment options have been studied and established. The appropriate choice depends on the severity of the defects and the age of the patient. EAPD encourages the use of all available treatment options, whilst in severe cases, scheduled extractions should be considered.

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Section: Comments Arising From the Evaluation Of The Existing Aetiology Literaturesupporting

confidence: 71%

Section: Aetiology Of Mihmentioning

confidence: 99%

Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Lygidakis

Garot

Somani

et al. 2021

Eur Arch Paediatr Dent

161

192

View full text Add to dashboard Cite

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“…Individual biologic influences on erosive tooth wear apparently are similar to the ones previously detected both for dental caries and dental erosive tooth wear (i.e., variation in genes involved in enamel formation) [7,8]. It is likely to assume that heritability should show modest values for dental erosive tooth wear similar to the ones found for dental caries [6] or molar-incisor hypomineralization [19] (around 20%). However, this is probably enough to determine important differences in frequency when environmental factors apparently are similar.…”

Section: Discussionsupporting

confidence: 69%

Protein Profiles of Individuals with Erosive Tooth Wear

Mulic

Tveit

Vieira

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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To determine if protein profiles identified in saliva could be used to determine risk and severity of erosive tooth wear. Material and Methods: Three types of saliva sampling were performed to obtain saliva from 34 18-year old individuals that received regular dental checkups , along with clinical status of the dentition and risk factor related to erosive tooth wear using the VEDE scale. Protein profiles in saliva were determined using electrophoresis and the calculation of the percentage of a specific band at a specific molecular weight in relationship to the total protein in that sample (% of total) using molecular weight standards. This quantification was repeated for each protein band across a range of molecular weights for each sample to test for association with erosive tooth wear status. Results: There were no differences in the number of detectable proteins sourced from the parotid gland, nor the unstimulated and stimulated whole saliva. Five out of the 34 individuals had no signs of erosive tooth wear despite an acidic diet and were more likely to have proteins with molecular weight smaller than 1 KDa (p=0.03). Conclusion: There is potential for the use of protein profiling to determine risks for erosive tooth wear.

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“…This definition influenced the work done for more than a decade that focused on the identification of an environmental etiological factor [27]. Our group brought to light the possibility that MIH, in fact, has a multifactorial mode of inheritance [2,5], and therefore has a genetic component, which was estimated in a proportion explaining the variation in the population of at least 20% based on data from twins [39]. Further, our group has proposed that MIH is possibly a localized and multifactorial expression of amelogenesis imperfecta [40].…”

Section: Discussionmentioning

confidence: 99%

Gene-environment interaction in molar-incisor hypomineralization

et al. 2021

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Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.

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On the genetics contribution to molar incisor hypomineralization

Cited by 18 publications

References 7 publications

Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Protein Profiles of Individuals with Erosive Tooth Wear

Gene-environment interaction in molar-incisor hypomineralization

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